Serum C-reactive protein as independent prognostic variable in patients with ovarian cancer

To evaluate serum C-reactive protein (CRP) as prognostic variable in patients with epithelial ovarian cancer (EOC). In a multicenter study, preoperative serum CRP was evaluated in 623 patients with EOC. Results were correlated with clinical data. Mean (SD) preoperative serum CRP was 3.6 (4.8) mg/dL....

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Veröffentlicht in:Clinical cancer research Jg. 14; H. 3; S. 710
Hauptverfasser: Hefler, Lukas A, Concin, Nicole, Hofstetter, Gerda, Marth, Christian, Mustea, Alexander, Sehouli, Jalid, Zeillinger, Robert, Leipold, Heinz, Lass, Harald, Grimm, Christoph, Tempfer, Clemens B, Reinthaller, Alexander
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.02.2008
Schlagworte:
Aged
Biomarkers, Tumor - blood
C-Reactive Protein - metabolism
Female
Humans
Middle Aged
Neoplasm Staging
Ovarian Neoplasms - blood
Ovarian Neoplasms - mortality
Ovarian Neoplasms - pathology
Ovarian Neoplasms - surgery
Prognosis
Retrospective Studies
Survival Analysis
ISSN:1078-0432
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Zusammenfassung:To evaluate serum C-reactive protein (CRP) as prognostic variable in patients with epithelial ovarian cancer (EOC). In a multicenter study, preoperative serum CRP was evaluated in 623 patients with EOC. Results were correlated with clinical data. Mean (SD) preoperative serum CRP was 3.6 (4.8) mg/dL. Serum CRP was significantly associated with International Federation of Gynecologists and Obstetricians stage (P < 0.001) and postoperative residual tumor mass (P < 0.001) but not with histologic grade (P = 0.1) and type (P = 0.7), patients' age (Pearson's correlation coefficient = 0.05; P = 0.2), and serum CA 125 (Pearson's correlation coefficient = 0.02; P = 0.6). Patients with platinum-resistant EOC had significantly higher CRP serum levels compared with patients with platinum-sensitive EOC [6.0 (6.6) mg/dL versus 2.8 (3.8) mg/dL; P < 0.001]. Higher International Federation of Gynecologists and Obstetricians stage (P < 0.001), presence of postoperative residual tumor mass (P < 0.001), tumor grade (P = 0.001), serum CA 125 (P = 0.03), and serum CRP (P = 0.001) were independently associated with overall survival. Patients with serum CRP < or =1 mg/dL versus >1 mg/dL had an overall 5-year survival of 82% versus 58.5% (P < 0.001). Serum CRP can be seen as a novel, widely available independent prognostic variable of ovarian cancer.
Bibliographie:ObjectType-Article-1
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ISSN:1078-0432
DOI:10.1158/1078-0432.CCR-07-1044