Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4 + T Cells in Peripheral Blood of Subjects with Type 1 Diabetes

The significance of islet Ag-reactive T cells found in peripheral blood of type 1 diabetes (T1D) subjects is unclear, partly because similar cells are also found in healthy control (HC) subjects. We hypothesized that key disease-associated cells would show evidence of prior Ag exposure, inferred fro...

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Vydáno v:	The Journal of immunology (1950) Ročník 199; číslo 1; s. 323
Hlavní autoři:	Cerosaletti, Karen, Barahmand-Pour-Whitman, Fariba, Yang, Junbao, DeBerg, Hannah A, Dufort, Matthew J, Murray, Sara A, Israelsson, Elisabeth, Speake, Cate, Gersuk, Vivian H, Eddy, James A, Reijonen, Helena, Greenbaum, Carla J, Kwok, William W, Wambre, Erik, Prlic, Martin, Gottardo, Raphael, Nepom, Gerald T, Linsley, Peter S
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.07.2017
Témata:	Adult CD4-Positive T-Lymphocytes - immunology Clone Cells Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - immunology Female Gene Expression Profiling Humans Immunologic Memory Islets of Langerhans - immunology Lymphocyte Activation Male Peptides - immunology Phenotype Receptors, Antigen, T-Cell, alpha-beta - immunology Sequence Analysis, RNA Single-Cell Analysis
ISSN:	1550-6606, 1550-6606
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