Activated protein C inhibits lipopolysaccharide‐mediated acetylation and secretion of high‐mobility group box 1 in endothelial cells

Essentials APC elicits cytoprotective responses in endothelial cells via EPCR‐dependent cleavage of PAR1. APC inhibits LPS‐mediated translocation and extracellular secretion of HMGB1 in endothelial cells. Signaling activity of APC inhibits LPS‐mediated acetylation of HMGB1 by epigenetic mechanisms....

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Veröffentlicht in:	Journal of thrombosis and haemostasis Jg. 17; H. 5; S. 803 - 817
Hauptverfasser:	Cai, Xiaofeng, Biswas, Indranil, Panicker, Sumith R., Giri, Hemant, Rezaie, Alireza R.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Limited 01.05.2019
Schlagworte:	Acetylation Activated protein C activated protein C Cytoplasm Endothelial cells endothelial protein C receptor HMGB1 HMGB1 protein Immunofluorescence Lipopolysaccharides Localization Lysates Membrane proteins Mobility protease‐activated receptor 1 Proteins Rodents Thrombin acetylation endothelial protein C receptor protease-activated receptor 1 HMGB1 activated protein C
ISSN:	1538-7933, 1538-7836, 1538-7836
Online-Zugang:	Volltext
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