Chlorpyrifos and dimethoate exposure impairs female fertility by deregulating WNT signaling pathway & uterine receptivity

The study assessed histological, biochemical, oxidative stress, and molecular parameters to evaluate the consequences of Chlorpyrifos and Dimethoate exposure on uterine health in female rats. Despite showing no obvious signs of toxicity apart from minor clinical symptoms in DM-exposed rats, both pes...

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Published in:Reproductive toxicology (Elmsford, N.Y.) Vol. 130; p. 108735
Main Authors: Jan, Jasmeena, Bashir, Showkeen Muzamil, Sheikh, Wajid Mohammad, Bhat, Owais Mohmad, Rafeeqi, Towseef Amin, Shah, Showkat Ahmad, Dar, Abid Hamid, Zargar, Mohammad Afzal, Wani, Nissar Ahmad
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.12.2024
Subjects:
Animals
Biochemical parameters
Chlorpyrifos
Chlorpyrifos - toxicity
Dimethoate
Dimethoate - toxicity
Female
Fertility - drug effects
Homeodomain Proteins - genetics
Homeodomain Proteins - metabolism
HOXA genes
Inflammation
Insecticides - toxicity
NF-kappa B - metabolism
Oxidative stress
Oxidative Stress - drug effects
Rats
Rats, Wistar
Uterine health
Uterus - drug effects
Uterus - metabolism
WNT genes
Wnt Signaling Pathway - drug effects
Chlorpyrifos
Oxidative stress
Uterine health
Biochemical parameters
WNT genes
HOXA genes
Inflammation
Dimethoate
ISSN:0890-6238, 1873-1708, 1873-1708
Online Access:Get full text
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Summary:The study assessed histological, biochemical, oxidative stress, and molecular parameters to evaluate the consequences of Chlorpyrifos and Dimethoate exposure on uterine health in female rats. Despite showing no obvious signs of toxicity apart from minor clinical symptoms in DM-exposed rats, both pesticides caused degenerative changes in uterine tissue. This study demonstrates that pesticides induce inflammatory responses and oxidative stress in rats, by NF-κB activation and altering antioxidant enzyme levels. Besides, CPF and DM exposure disrupted gene expression of HOXA10, HOXA11, and WNT and reduced activation of β-catenin in the uterus, which is crucial for implantation and reproductive function. These findings suggest that pesticide exposure may impair reproductive health and fertility in females, highlighting potential implications for human health. [Display omitted] •CPM and DM exposure induce severe structural damage in the uterus of female rats.•CPM and DM exposure impairs biochemical and metabolic parameters of female rats.•Pesticide exposure undermines the oxidative defense mechanism.•Dysregulation of WNT signaling and genes related to uterine development & receptivity.•These alterations suggested compromised uterine function, thereby fertility.
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ISSN:0890-6238
1873-1708
1873-1708
DOI:10.1016/j.reprotox.2024.108735