Longitudinal assessment of loss and gain of lung function in childhood asthma
The Childhood Asthma Management Program revealed that 25.7% of children with mild to moderate asthma exhibit loss of lung function. The objective was to assess the trajectories of function by means of serial FEV 1 in asthmatic children participating in out-of-hospital follow-up. A total of 295 child...
Saved in:
| Published in: | The Journal of asthma Vol. 60; no. 1; pp. 24 - 31 |
|---|---|
| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Taylor & Francis
02.01.2023
|
| Subjects: | |
| ISSN: | 0277-0903, 1532-4303, 1532-4303 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | The Childhood Asthma Management Program revealed that 25.7% of children with mild to moderate asthma exhibit loss of lung function. The objective was to assess the trajectories of function by means of serial FEV
1
in asthmatic children participating in out-of-hospital follow-up.
A total of 295 children (199 boys) who had undergone at least 10 spirometry tests from the age of 8 were selected from a single-center open cohort. The annualized rate of change (slope) for prebronchodilator FEV
1
(percent predicted) was estimated for each participant and three patterns were defined: significantly positive slope, significantly negative slope, and null slope (non-significant P-value; Pearson test). The standard deviation (SD) of each individual slope was recorded as a variability criterion of FEV
1
.
The median (25
th
; 75
th
percentile) age at inclusion and the last visit was 8.5 (8.2; 9.3) and 15.4 (14.8, 16.0) years, respectively. Tracking of function (null slope) was observed in 68.8% of the children, while 27.8% showed a loss of function or reduced growth (negative slope) and 3.4% showed a gain in function (positive slope). The children characterized by loss of function depicted a better initial function and a lower FEV
1
variability during their follow-up than children with tracking or gain of lung function. At the last visit, these children were characterized by a lower lung function than children with tracking or gain of lung function.
Better initial FEV
1
value and less FEV
1
variability are associated with loss of lung function or reduced lung growth in asthmatic children. |
|---|---|
| AbstractList | The Childhood Asthma Management Program revealed that 25.7% of children with mild to moderate asthma exhibit loss of lung function. The objective was to assess the trajectories of function by means of serial FEV
in asthmatic children participating in out-of-hospital follow-up.
A total of 295 children (199 boys) who had undergone at least 10 spirometry tests from the age of 8 were selected from a single-center open cohort. The annualized rate of change (slope) for prebronchodilator FEV
(percent predicted) was estimated for each participant and three patterns were defined: significantly positive slope, significantly negative slope, and null slope (non-significant P-value; Pearson test). The standard deviation (SD) of each individual slope was recorded as a variability criterion of FEV
.
The median (25
; 75
percentile) age at inclusion and the last visit was 8.5 (8.2; 9.3) and 15.4 (14.8, 16.0) years, respectively. Tracking of function (null slope) was observed in 68.8% of the children, while 27.8% showed a loss of function or reduced growth (negative slope) and 3.4% showed a gain in function (positive slope). The children characterized by loss of function depicted a better initial function and a lower FEV
variability during their follow-up than children with tracking or gain of lung function. At the last visit, these children were characterized by a lower lung function than children with tracking or gain of lung function.
Better initial FEV
value and less FEV
variability are associated with loss of lung function or reduced lung growth in asthmatic children. The Childhood Asthma Management Program revealed that 25.7% of children with mild to moderate asthma exhibit loss of lung function. The objective was to assess the trajectories of function by means of serial FEV 1 in asthmatic children participating in out-of-hospital follow-up. A total of 295 children (199 boys) who had undergone at least 10 spirometry tests from the age of 8 were selected from a single-center open cohort. The annualized rate of change (slope) for prebronchodilator FEV 1 (percent predicted) was estimated for each participant and three patterns were defined: significantly positive slope, significantly negative slope, and null slope (non-significant P-value; Pearson test). The standard deviation (SD) of each individual slope was recorded as a variability criterion of FEV 1 . The median (25 th ; 75 th percentile) age at inclusion and the last visit was 8.5 (8.2; 9.3) and 15.4 (14.8, 16.0) years, respectively. Tracking of function (null slope) was observed in 68.8% of the children, while 27.8% showed a loss of function or reduced growth (negative slope) and 3.4% showed a gain in function (positive slope). The children characterized by loss of function depicted a better initial function and a lower FEV 1 variability during their follow-up than children with tracking or gain of lung function. At the last visit, these children were characterized by a lower lung function than children with tracking or gain of lung function. Better initial FEV 1 value and less FEV 1 variability are associated with loss of lung function or reduced lung growth in asthmatic children. The Childhood Asthma Management Program revealed that 25.7% of children with mild to moderate asthma exhibit loss of lung function. The objective was to assess the trajectories of function by means of serial FEV1 in asthmatic children participating in out-of-hospital follow-up.OBJECTIVEThe Childhood Asthma Management Program revealed that 25.7% of children with mild to moderate asthma exhibit loss of lung function. The objective was to assess the trajectories of function by means of serial FEV1 in asthmatic children participating in out-of-hospital follow-up.A total of 295 children (199 boys) who had undergone at least 10 spirometry tests from the age of 8 were selected from a single-center open cohort. The annualized rate of change (slope) for prebronchodilator FEV1 (percent predicted) was estimated for each participant and three patterns were defined: significantly positive slope, significantly negative slope, and null slope (non-significant P-value; Pearson test). The standard deviation (SD) of each individual slope was recorded as a variability criterion of FEV1.METHODSA total of 295 children (199 boys) who had undergone at least 10 spirometry tests from the age of 8 were selected from a single-center open cohort. The annualized rate of change (slope) for prebronchodilator FEV1 (percent predicted) was estimated for each participant and three patterns were defined: significantly positive slope, significantly negative slope, and null slope (non-significant P-value; Pearson test). The standard deviation (SD) of each individual slope was recorded as a variability criterion of FEV1.The median (25th; 75th percentile) age at inclusion and the last visit was 8.5 (8.2; 9.3) and 15.4 (14.8, 16.0) years, respectively. Tracking of function (null slope) was observed in 68.8% of the children, while 27.8% showed a loss of function or reduced growth (negative slope) and 3.4% showed a gain in function (positive slope). The children characterized by loss of function depicted a better initial function and a lower FEV1 variability during their follow-up than children with tracking or gain of lung function. At the last visit, these children were characterized by a lower lung function than children with tracking or gain of lung function.RESULTSThe median (25th; 75th percentile) age at inclusion and the last visit was 8.5 (8.2; 9.3) and 15.4 (14.8, 16.0) years, respectively. Tracking of function (null slope) was observed in 68.8% of the children, while 27.8% showed a loss of function or reduced growth (negative slope) and 3.4% showed a gain in function (positive slope). The children characterized by loss of function depicted a better initial function and a lower FEV1 variability during their follow-up than children with tracking or gain of lung function. At the last visit, these children were characterized by a lower lung function than children with tracking or gain of lung function.Better initial FEV1 value and less FEV1 variability are associated with loss of lung function or reduced lung growth in asthmatic children.CONCLUSIONBetter initial FEV1 value and less FEV1 variability are associated with loss of lung function or reduced lung growth in asthmatic children. |
| Author | Bokov, Plamen Delclaux, Christophe Beydon, Nicole Mahut, Bruno |
| Author_xml | – sequence: 1 givenname: Bruno surname: Mahut fullname: Mahut, Bruno organization: Clinique La Berma – sequence: 2 givenname: Plamen surname: Bokov fullname: Bokov, Plamen organization: Service de Physiologie Pédiatrique-Centre du Sommeil, INSERM NeuroDiderot, Université de Paris, AP-HP, Hôpital Robert Debré – sequence: 3 givenname: Nicole surname: Beydon fullname: Beydon, Nicole organization: Service de Physiologie Pédiatrique-Centre du Sommeil, AP-HP, Hôpital Armand Trousseau – sequence: 4 givenname: Christophe orcidid: 0000-0003-2786-0812 surname: Delclaux fullname: Delclaux, Christophe organization: Service de Physiologie Pédiatrique-Centre du Sommeil, INSERM NeuroDiderot, Université de Paris, AP-HP, Hôpital Robert Debré |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34958615$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkE1P3DAQhq0KVBboT2iVYy-B8UeSXfXSCvElLeICZ2sS27uuHJvajhD_HofdvfTQXjzS6HnHep9TcuSD14R8pXBBYQmXwLoOVsAvGDA6P5x27SeyoA1nteDAj8hiZuoZOiGnKf0GKAtoP5MTLlbNsqXNgjysg9_YPCnr0VWYkk5p1D5XwVQupFShV9UGrf9YTH5TmckP2QZfld2wtU5tQ1AlmbcjnpNjgy7pL_t5Rp5vrp-u7ur14-391a91PfC2zbVZih5AaA4r1QN2VIneKNYooEwJFMJoqnnHdWMYNaiV7jQapno1NJr3gp-R77u7LzH8mXTKcrRp0M6h12FKkpVutJigbUG_7dGpH7WSL9GOGN_kQUEBfuyAIZa-URs52IxzwxzROklBzsLlQbichcu98JJu_kofPvhf7ucuZ70JccTXEJ2SGd9ciCaiH2yS_N8n3gEH2JdB |
| CitedBy_id | crossref_primary_10_1002_ppul_71295 |
| Cites_doi | 10.1016/S2213-2600(18)30100-0 10.1136/bjsm.31.4.337 10.1002/ppul.22876 10.4168/aair.2019.11.6.763 10.1164/rccm.201604-0753OC 10.3109/02770901003615786 10.1164/rccm.201110-1922OC 10.1016/j.jaci.2006.07.053 10.1186/1465-9921-12-65 10.1513/AnnalsATS.201904-329OC 10.1183/09031936.05.00034805 10.1164/rccm.200504-619OC 10.1164/rccm.200308-1178OC 10.1183/23120541.00320-2020 10.1183/09031936.00080312 10.1183/09031936.00103311 10.1016/j.jaci.2006.01.050 10.1164/ajrccm.164.5.2011026 10.1164/rccm.200801-060ST 10.1016/j.rmed.2020.106202 10.1164/rccm.200807-1126OC 10.1056/NEJMoa022363 10.1164/rccm.200308-1174OC 10.1056/NEJMra1603287 10.1378/chest.07-0713 10.1034/j.1399-3003.1999.13d35.x 10.1111/j.1440-1843.2011.01953.x 10.1056/NEJMoa1513737 10.1513/AnnalsATS.201808-564PS 10.1056/NEJM200010123431501 10.1164/rccm.202002-0454OC 10.1016/j.jaci.2008.09.004 |
| ContentType | Journal Article |
| Copyright | 2022 Taylor & Francis Group, LLC 2022 |
| Copyright_xml | – notice: 2022 Taylor & Francis Group, LLC 2022 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1080/02770903.2021.2023176 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1532-4303 |
| EndPage | 31 |
| ExternalDocumentID | 34958615 10_1080_02770903_2021_2023176 2023176 |
| Genre | Research Article Journal Article |
| GroupedDBID | --- 00X 03L 0R~ 29J 36B 4.4 5GY 5RE AAGDL AALUX AAMIU AAPUL AAQRR ABBKH ABEIZ ABIVO ABJNI ABLIJ ABLKL ABUPF ABWVI ABXYU ACENM ACGEJ ACGFO ACGFS ACIEZ ADCVX ADRBQ ADXPE AECIN AEGXH AENEX AEOZL AFKVX AFRVT AGDLA AGFJD AGRBW AGYJP AIJEM AIRBT AJWEG AKBVH ALMA_UNASSIGNED_HOLDINGS ALQZU ALYBC AMDAE AQTUD BABNJ BLEHA BOHLJ CCCUG CS3 DKSSO DU5 EBS EJD F5P FEDTE H13 HVGLF HZ~ KRBQP KSSTO KWAYT KYCEM LJTGL M4Z O9- RNANH RVRKI SJN TASJS TBQAZ TDBHL TERGH TFDNU TFL TFW TUROJ UEQFS V1S ~1N AAYXX CITATION .55 .GJ 3O- 53G 5VS AALIY AAORF AAPXX ABWCV ABZEW ACKZS ACOPL ADFOM ADFZZ ADYSH AEIIZ AFFNX AFLEI AJVHN AWYRJ BRMBE CAG CGR COF CUY CVF CYYVM CZDIS DRXRE DWTOO ECM EIF JENTW M44 NPM NUSFT QQXMO X7M ZGI ZXP 7X8 |
| ID | FETCH-LOGICAL-c366t-f84b004e309db0a71d4bfd25d012d4a44fe1e373e5f21faede7eaf2dbdc5e3b43 |
| IEDL.DBID | TFW |
| ISICitedReferencesCount | 2 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000738396800001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0277-0903 1532-4303 |
| IngestDate | Thu Oct 02 05:35:49 EDT 2025 Thu Apr 03 06:53:57 EDT 2025 Sat Nov 29 04:53:24 EST 2025 Tue Nov 18 21:06:24 EST 2025 Mon Oct 20 23:48:01 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Spirometry forced expiratory volume in 1 s lung function variability |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c366t-f84b004e309db0a71d4bfd25d012d4a44fe1e373e5f21faede7eaf2dbdc5e3b43 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-2786-0812 |
| PMID | 34958615 |
| PQID | 2615115316 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | crossref_citationtrail_10_1080_02770903_2021_2023176 pubmed_primary_34958615 informaworld_taylorfrancis_310_1080_02770903_2021_2023176 proquest_miscellaneous_2615115316 crossref_primary_10_1080_02770903_2021_2023176 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-01-02 |
| PublicationDateYYYYMMDD | 2023-01-02 |
| PublicationDate_xml | – month: 01 year: 2023 text: 2023-01-02 day: 02 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | The Journal of asthma |
| PublicationTitleAlternate | J Asthma |
| PublicationYear | 2023 |
| Publisher | Taylor & Francis |
| Publisher_xml | – name: Taylor & Francis |
| References | CIT0030 CIT0010 CIT0032 CIT0031 CIT0012 CIT0011 CIT0014 CIT0013 CIT0016 CIT0015 CIT0018 CIT0017 CIT0019 CIT0021 CIT0020 CIT0001 CIT0023 CIT0022 CIT0003 CIT0025 CIT0002 CIT0024 CIT0005 CIT0027 CIT0004 CIT0026 CIT0007 CIT0029 CIT0006 CIT0028 CIT0009 CIT0008 |
| References_xml | – ident: CIT0028 doi: 10.1016/S2213-2600(18)30100-0 – ident: CIT0029 doi: 10.1136/bjsm.31.4.337 – ident: CIT0013 doi: 10.1002/ppul.22876 – ident: CIT0027 doi: 10.4168/aair.2019.11.6.763 – ident: CIT0030 doi: 10.1164/rccm.201604-0753OC – ident: CIT0015 doi: 10.3109/02770901003615786 – ident: CIT0002 doi: 10.1164/rccm.201110-1922OC – ident: CIT0003 doi: 10.1016/j.jaci.2006.07.053 – ident: CIT0009 doi: 10.1186/1465-9921-12-65 – ident: CIT0019 doi: 10.1513/AnnalsATS.201904-329OC – ident: CIT0011 doi: 10.1183/09031936.05.00034805 – ident: CIT0022 doi: 10.1164/rccm.200504-619OC – ident: CIT0020 doi: 10.1164/rccm.200308-1178OC – ident: CIT0021 doi: 10.1183/23120541.00320-2020 – ident: CIT0012 doi: 10.1183/09031936.00080312 – ident: CIT0024 doi: 10.1183/09031936.00103311 – ident: CIT0026 doi: 10.1016/j.jaci.2006.01.050 – ident: CIT0031 doi: 10.1164/ajrccm.164.5.2011026 – ident: CIT0010 doi: 10.1164/rccm.200801-060ST – ident: CIT0025 doi: 10.1016/j.rmed.2020.106202 – ident: CIT0008 doi: 10.1164/rccm.200807-1126OC – ident: CIT0016 doi: 10.1056/NEJMoa022363 – ident: CIT0004 doi: 10.1164/rccm.200308-1174OC – ident: CIT0001 doi: 10.1056/NEJMra1603287 – ident: CIT0032 doi: 10.1378/chest.07-0713 – ident: CIT0023 doi: 10.1034/j.1399-3003.1999.13d35.x – ident: CIT0007 doi: 10.1111/j.1440-1843.2011.01953.x – ident: CIT0017 doi: 10.1056/NEJMoa1513737 – ident: CIT0006 doi: 10.1513/AnnalsATS.201808-564PS – ident: CIT0005 doi: 10.1056/NEJM200010123431501 – ident: CIT0014 doi: 10.1164/rccm.202002-0454OC – ident: CIT0018 doi: 10.1016/j.jaci.2008.09.004 |
| SSID | ssj0002706 |
| Score | 2.3428004 |
| Snippet | The Childhood Asthma Management Program revealed that 25.7% of children with mild to moderate asthma exhibit loss of lung function. The objective was to assess... |
| SourceID | proquest pubmed crossref informaworld |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 24 |
| SubjectTerms | Asthma - diagnosis Child Forced Expiratory Volume forced expiratory volume in 1 s Humans Lung lung function variability Male Respiratory Function Tests Spirometry Vital Capacity |
| Title | Longitudinal assessment of loss and gain of lung function in childhood asthma |
| URI | https://www.tandfonline.com/doi/abs/10.1080/02770903.2021.2023176 https://www.ncbi.nlm.nih.gov/pubmed/34958615 https://www.proquest.com/docview/2615115316 |
| Volume | 60 |
| WOSCitedRecordID | wos000738396800001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAWR databaseName: Taylor & Francis Journals customDbUrl: eissn: 1532-4303 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0002706 issn: 0277-0903 databaseCode: TFW dateStart: 19810101 isFulltext: true titleUrlDefault: https://www.tandfonline.com providerName: Taylor & Francis |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LT8MwDI4AIcSF9_uhIHEtLI8u2REhJg5s4gBityqJE0CCDrGO30-cthMcEAc4VKqSukmdOLbj9DMhpx2ba4AcMtYFnck8d1nPOp11rA7cdRmDIFOyCTUc6tGod9ucJpw0xyrRhw41UERaq1G4jZ20J-LOMeyI2wvRu-Po4kUTRSHodlT9KJp3_YfZWsxVyq6ZApVI0v7D89Nbvmmnb9ilP1ugSRP1V__hG9bISmOG0ot63qyTOV9ukKVBE2jfJIObMSYymgImzaJmBt9Jx4G-xJ7T2DB9NM9lKogLBkUFiYNMY5lr8ZIjZfX0arbIff_q7vI6azIvZE50u1UWtERx9qLTA9sxioG0AXgOUZ2BNFIGz7xQwueBs2A8eOVN4GDB5V5YKbbJQjku_S6h3kcjRjtQzAdppbZCxwuMEsAVcL5HZMvxwjWw5Jgd46VgLXppw6oCWVU0rNojZzOytxqX4zeC3tfhLKq0IRLq7CWF-IX2pB37IkofhlRM6cfTScHRIIxKg8VndupJMeuOiL6njvX7f2j5gCzjXdrz4YdkoXqf-iOy6D6q58n7MZlXI32cZvwnJ9n5rQ |
| linkProvider | Taylor & Francis |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LbxMxELagVKWXUt594kpcF-LHrp1jhYiKmuQURG6W7bGhUtmgdsPvx-PdjZpDlEM57MW7s7bHj3nZ3xDyceBKDVBCwSrQhSxLXwyd18XA6ch9xRhEmZNNqOlUz-fDh3dh8Fgl2tCxBYrIezUubnRG90fiPmPcEf0LybzjaOMlHUVVT8mzMslaxM-fjX6sdmOucn7NHKpEmv4Wz6bfrMmnNfTSzTpolkWjF_-jF4fkoNNE6WU7dV6SJ6F-RfYmXaz9NZmMF5jLaAmYN4vaFYInXUR6m5pOU830p72pc0HaMyjKSBxnmsp8D5mcKJtfv-0b8n30dfblquiSLxReVFVTRC1xRQcxGIIbWMVAugi8hCTRQFopY2BBKBHKyFm0AYIKNnJw4MsgnBRvyU69qMN7QkNIeoz2oFiI0knthE4PWCWAK-D8iMie5cZ3yOSYIOPWsB7AtGOVQVaZjlVH5NOK7E8LzbGNYPhwPE2TfSKxTWBixBbai37wTVqAGFWxdVgs7w1HnTDJDZa-edfOilVzRDI_dXp__IiaP5DnV7PJ2Iy_Ta9PyD6WZhcQPyU7zd0ynJFd_7e5ub87zxP_Hx3J_O8 |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LT9wwELbKtkK9lNKWllcxUq9p14_E3iMCVlSFFQdQuVm2xwYkyKLdbH9_PU6yKgfEoRxycTKxMx57Xs43hHwbulIDlFCwCnQhy9IXI-d1MXQ6cl8xBlHmYhNqMtFXV6Pz7jThvDtWiT50bIEi8l6Ni_sBYn8i7gemHTG8kLw7ji5eMlFUtUJeJ9O5QiG_GP9ebsZc5fKaOVOJNP1PPE-95pF6egRe-rQJmlXReO0FPuI9edfZofSgFZx18irUH8jqWZdp_0jOTqdYyWgBWDWL2iV-J51GepdGTlPH9Nre1rkh7RgUNSTOMk1tvgdMTpTNzb39RC7HxxeHJ0VXeqHwoqqaImqJ6zmI4Qjc0CoG0kXgJSR9BtJKGQMLQolQRs6iDRBUsJGDA18G4aTYIIN6WocvhIaQrBjtQbEQpZPaCZ0usEoAV8D5JpE9x43vcMmxPMadYT18accqg6wyHas2yfcl2UMLzPEcwejf6TRNjojEtnyJEc_Q7vdzb9Lyw5yKrcN0MTccLcKkNVh65nMrFMvhiOR86nR_6z963iOr50djc_pz8mubvMXGHP_hO2TQzBZhl7zxf5rb-exrFvu_HFz7oQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Longitudinal+assessment+of+loss+and+gain+of+lung+function+in+childhood+asthma&rft.jtitle=The+Journal+of+asthma&rft.au=Mahut%2C+Bruno&rft.au=Bokov%2C+Plamen&rft.au=Beydon%2C+Nicole&rft.au=Delclaux%2C+Christophe&rft.date=2023-01-02&rft.pub=Taylor+%26+Francis&rft.issn=0277-0903&rft.eissn=1532-4303&rft.volume=60&rft.issue=1&rft.spage=24&rft.epage=31&rft_id=info:doi/10.1080%2F02770903.2021.2023176&rft.externalDocID=2023176 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0277-0903&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0277-0903&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0277-0903&client=summon |