Longitudinal assessment of loss and gain of lung function in childhood asthma

The Childhood Asthma Management Program revealed that 25.7% of children with mild to moderate asthma exhibit loss of lung function. The objective was to assess the trajectories of function by means of serial FEV 1 in asthmatic children participating in out-of-hospital follow-up. A total of 295 child...

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Bibliographic Details
Published in:The Journal of asthma Vol. 60; no. 1; pp. 24 - 31
Main Authors: Mahut, Bruno, Bokov, Plamen, Beydon, Nicole, Delclaux, Christophe
Format: Journal Article
Language:English
Published: England Taylor & Francis 02.01.2023
Subjects:
Asthma - diagnosis
Child
Forced Expiratory Volume
forced expiratory volume in 1 s
Humans
Lung
lung function variability
Male
Respiratory Function Tests
Spirometry
Vital Capacity
Spirometry
forced expiratory volume in 1 s
lung function variability
ISSN:0277-0903, 1532-4303, 1532-4303
Online Access:Get full text
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Summary:The Childhood Asthma Management Program revealed that 25.7% of children with mild to moderate asthma exhibit loss of lung function. The objective was to assess the trajectories of function by means of serial FEV 1 in asthmatic children participating in out-of-hospital follow-up. A total of 295 children (199 boys) who had undergone at least 10 spirometry tests from the age of 8 were selected from a single-center open cohort. The annualized rate of change (slope) for prebronchodilator FEV 1 (percent predicted) was estimated for each participant and three patterns were defined: significantly positive slope, significantly negative slope, and null slope (non-significant P-value; Pearson test). The standard deviation (SD) of each individual slope was recorded as a variability criterion of FEV 1 . The median (25 th ; 75 th percentile) age at inclusion and the last visit was 8.5 (8.2; 9.3) and 15.4 (14.8, 16.0) years, respectively. Tracking of function (null slope) was observed in 68.8% of the children, while 27.8% showed a loss of function or reduced growth (negative slope) and 3.4% showed a gain in function (positive slope). The children characterized by loss of function depicted a better initial function and a lower FEV 1 variability during their follow-up than children with tracking or gain of lung function. At the last visit, these children were characterized by a lower lung function than children with tracking or gain of lung function. Better initial FEV 1 value and less FEV 1 variability are associated with loss of lung function or reduced lung growth in asthmatic children.
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ISSN:0277-0903
1532-4303
1532-4303
DOI:10.1080/02770903.2021.2023176