Generation of human oogonia from induced pluripotent stem cells in vitro

Human in vitro gametogenesis may transform reproductive medicine. Human pluripotent stem cells (hPSCs) have been induced into primordial germ cell-like cells (hPGCLCs); however, further differentiation to a mature germ cell has not been achieved. Here, we show that hPGCLCs differentiate progressivel...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 362; H. 6412; S. 356
Hauptverfasser:	Yamashiro, Chika, Sasaki, Kotaro, Yabuta, Yukihiro, Kojima, Yoji, Nakamura, Tomonori, Okamoto, Ikuhiro, Yokobayashi, Shihori, Murase, Yusuke, Ishikura, Yukiko, Shirane, Kenjiro, Sasaki, Hiroyuki, Yamamoto, Takuya, Saitou, Mitinori
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 19.10.2018
Schlagworte:	Cellular Reprogramming Techniques - methods DNA Methylation Epigenesis, Genetic Female Humans Induced Pluripotent Stem Cells - cytology Oogenesis Oogonia - cytology Ovary - growth & development
ISSN:	1095-9203, 1095-9203
Online-Zugang:	Weitere Angaben
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