Protective role of polyphenols from Bauhinia hookeri against carbon tetrachloride-induced hepato- and nephrotoxicity in mice

The hepatoprotective and nephroprotective activity of a polyphenol-rich fraction (BHPF) obtained from Bauhinia hookeri was investigated against CCl 4 -induced acute hepatorenal toxicity in mice. BHPF was administered (100, 200 and 400 mg/kg/day) for 5 days, then CCl 4 was administered. BHPF pretreat...

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Bibliographic Details
Published in:	Renal failure Vol. 37; no. 7; pp. 1198 - 1207
Main Authors:	Al-Sayed, Eman, Abdel-Daim, Mohamed M., Kilany, Omnia E., Karonen, Maarit, Sinkkonen, Jari
Format:	Journal Article
Language:	English
Published:	England Informa Healthcare 09.08.2015
Subjects:	Animals Antioxidant Bauhinia Carbon Tetrachloride - toxicity Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury - prevention & control Chromatography, High Pressure Liquid epicatechin gallate Glutathione - metabolism hepatoprotective HPLC-PDA-ESI/MS/MS kidney Kidney - pathology Lipid Peroxidation - drug effects liver Male Malondialdehyde - metabolism Mice nephroprotective Oxidative Stress - drug effects Plant Extracts - pharmacology Polyphenols - administration & dosage proanthocyanidins Protective Agents - administration & dosage Superoxide Dismutase - metabolism kidney proanthocyanidins liver epicatechin gallate Antioxidant HPLC-PDA-ESI/MS/MS nephroprotective hepatoprotective
ISSN:	0886-022X, 1525-6049, 1525-6049
Online Access:	Get full text
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