Protective role of polyphenols from Bauhinia hookeri against carbon tetrachloride-induced hepato- and nephrotoxicity in mice

The hepatoprotective and nephroprotective activity of a polyphenol-rich fraction (BHPF) obtained from Bauhinia hookeri was investigated against CCl 4 -induced acute hepatorenal toxicity in mice. BHPF was administered (100, 200 and 400 mg/kg/day) for 5 days, then CCl 4 was administered. BHPF pretreat...

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Published in:Renal failure Vol. 37; no. 7; pp. 1198 - 1207
Main Authors: Al-Sayed, Eman, Abdel-Daim, Mohamed M., Kilany, Omnia E., Karonen, Maarit, Sinkkonen, Jari
Format: Journal Article
Language:English
Published: England Informa Healthcare 09.08.2015
Subjects:
Animals
Antioxidant
Bauhinia
Carbon Tetrachloride - toxicity
Chemical and Drug Induced Liver Injury - pathology
Chemical and Drug Induced Liver Injury - prevention & control
Chromatography, High Pressure Liquid
epicatechin gallate
Glutathione - metabolism
hepatoprotective
HPLC-PDA-ESI/MS/MS
kidney
Kidney - pathology
Lipid Peroxidation - drug effects
liver
Male
Malondialdehyde - metabolism
Mice
nephroprotective
Oxidative Stress - drug effects
Plant Extracts - pharmacology
Polyphenols - administration & dosage
proanthocyanidins
Protective Agents - administration & dosage
Superoxide Dismutase - metabolism
kidney
proanthocyanidins
liver
epicatechin gallate
Antioxidant
HPLC-PDA-ESI/MS/MS
nephroprotective
hepatoprotective
ISSN:0886-022X, 1525-6049, 1525-6049
Online Access:Get full text
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Summary:The hepatoprotective and nephroprotective activity of a polyphenol-rich fraction (BHPF) obtained from Bauhinia hookeri was investigated against CCl 4 -induced acute hepatorenal toxicity in mice. BHPF was administered (100, 200 and 400 mg/kg/day) for 5 days, then CCl 4 was administered. BHPF pretreatment significantly (p < 0.001) inhibited the CCl 4 -induced increase in ALT, AST, ALP, LDH, total bilirubin, cholesterol, creatinine, uric acid, urea and malondialdehyde in a dose-dependent manner. In contrast, BHPF pretreatment markedly increased the contents of glutathione and superoxide dismutase in the liver and kidney tissues, indicating the strong in vivo antioxidant activity of BHPF. Pretreatment with BHPF preserved the hepatic architecture and conferred marked protection against necrosis and ballooning degeneration. Pretreatment with BHPF reduced the inflammatory cell aggregation and degenerative changes in the lining epithelium of the kidney tubules. It can be concluded that BHPF has a remarkable hepato- and nephroprotective activity by enhancing the antioxidant defense status, reducing lipid peroxidation and protecting against the histopathological changes induced by CCl 4 in the liver and kidney tissues.
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ISSN:0886-022X
1525-6049
1525-6049
DOI:10.3109/0886022X.2015.1061886