Intracellular trafficking and cytotoxicity of a gelatine-doxorubicin conjugate in two breast cancer cell lines

Details of intracellular pathways of cytotoxicity remain unclear for doxorubicin conjugates being studied to treat breast cancer tumours. A high molecular weight gelatine-doxorubicin conjugate was investigated with an emphasis on lysosome participation. The conjugate was synthesised and characterise...

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Bibliographic Details

Published in:	Journal of drug targeting Vol. 28; no. 5; pp. 487 - 499
Main Authors:	Alvi, Mohammed M., Nicoletto, Rachel E., Eshmawi, Bayan A., Kim, Hyun (Kate), Cammarata, Christopher R., Ofner, Clyde M.
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 27.05.2020
Subjects:	conjugate cytotoxicity doxorubicin Gelatine lysosome membrane permeabilization MCF-7 MDA-MB-231 conjugate MCF-7 doxorubicin lysosome membrane permeabilization Gelatine MDA-MB-231 cytotoxicity
ISSN:	1061-186X, 1029-2330, 1029-2330
Online Access:	Get full text
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