Effects of fluconazole on the pharmacokinetics of celecoxib and its carboxylic acid metabolite in different CYP2C9 genotypes

This study aimed to investigate the effects of fluconazole, a moderate inhibitor of CYP2C9 and CYP3A4, on the pharmacokinetics of celecoxib and its carboxylic acid metabolite in different CYP2C9 genotypes. A total of thirty-nine healthy Korean male volunteers were divided into three different CYP2C9...

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Vydané v:	Archives of pharmacal research Ročník 48; číslo 3; s. 224 - 233
Hlavní autori:	Cho, Chang-Keun, Kang, Pureum, Jang, Choon-Gon, Lee, Yun Jeong, Bae, Jung-Woo, Choi, Chang-Ik, Lee, Seok-Yong
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Seoul Pharmaceutical Society of Korea 01.03.2025 대한약학회
Predmet:	Administration, Oral Adult Antifungal Agents - administration & dosage Antifungal Agents - pharmacology carboxylic acids Carboxylic Acids - metabolism Carboxylic Acids - pharmacokinetics Celecoxib - administration & dosage Celecoxib - blood Celecoxib - pharmacokinetics Cyclooxygenase 2 Inhibitors - administration & dosage Cyclooxygenase 2 Inhibitors - pharmacokinetics Cytochrome P-450 CYP2C9 - genetics Cytochrome P-450 CYP2C9 - metabolism Drug Interactions fluconazole Fluconazole - administration & dosage Fluconazole - pharmacology Genotype Healthy Volunteers Humans Male males Medicine metabolites oral administration pharmacokinetics Pharmacology/Toxicology Pharmacy Research Article Young Adult 약학 CYP2C9 Genotype Celecoxib Fluconazole Pharmacokinetics Celecoxib carboxylic acid
ISSN:	0253-6269, 1976-3786, 1976-3786
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