Investigation of microemulsion microstructure and its impact on skin delivery of flufenamic acid

[Display omitted] Microemulsions are well known penetration enhancing delivery systems. Several properties are described that influence the transdermal delivery of active components. Therefore, this study aimed to characterize fluorosurfactant-based microemulsions and to assess the impact of formula...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	International journal of pharmaceutics Ročník 490; číslo 1-2; s. 292 - 297
Hlavní autoři:	Mahrhauser, Denise-Silvia, Kählig, Hanspeter, Partyka-Jankowska, Ewa, Peterlik, Herwig, Binder, Lisa, Kwizda, Kristina, Valenta, Claudia
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier B.V 25.07.2015
Témata:	Administration, Cutaneous Chemistry, Pharmaceutical - methods Drug Delivery Systems - methods Electrical conductivity Emulsions - administration & dosage Emulsions - chemistry Flufenamic Acid - administration & dosage Flufenamic Acid - chemistry Microemulsion characterization NMR Permeability SAXS Scattering, Small Angle Skin - metabolism Skin Absorption Skin permeation studies Solvents - chemistry Surface-Active Agents - chemistry Water - chemistry X-Ray Diffraction - methods Skin permeation studies NMR Electrical conductivity Microemulsion characterization ME Sin Hex SAXS
ISSN:	0378-5173, 1873-3476
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	[Display omitted] Microemulsions are well known penetration enhancing delivery systems. Several properties are described that influence the transdermal delivery of active components. Therefore, this study aimed to characterize fluorosurfactant-based microemulsions and to assess the impact of formulation variables on the transdermal delivery of incorporated flufenamic acid. The microemulsion systems prepared in this study consisted of bistilled water, oleic acid, isopropanol as co-solvent, flufenamic acid as active ingredient and either HexaforTM670 (Hex) or Chemguard S-550-100 (Sin) as fluorosurfactant. Characterization was performed by a combination of techniques including electrical conductivity measurements, small-angle X-ray scattering (SAXS) and nuclear magnetic resonance (NMR) self-diffusion experiments. In vitro skin permeation experiments were performed with each prepared microemulsion using Franz type diffusion cells to correlate their present microstructure with their drug delivery to skin. Electrical conductivity increased with added water content. Consequently, the absence of a conductivity maximum as well as the NMR and SAXS data rather suggest O/W type microemulsions with spherical or rod-like microstructures. Skin permeation data revealed enhanced diffusion for Hex- and Sin-microemulsions if the shape of the structures was rather elongated than spherical implying that the shape of droplets had an essential impact on the skin permeation of flufenamic acid.
AbstractList	[Display omitted] Microemulsions are well known penetration enhancing delivery systems. Several properties are described that influence the transdermal delivery of active components. Therefore, this study aimed to characterize fluorosurfactant-based microemulsions and to assess the impact of formulation variables on the transdermal delivery of incorporated flufenamic acid. The microemulsion systems prepared in this study consisted of bistilled water, oleic acid, isopropanol as co-solvent, flufenamic acid as active ingredient and either HexaforTM670 (Hex) or Chemguard S-550-100 (Sin) as fluorosurfactant. Characterization was performed by a combination of techniques including electrical conductivity measurements, small-angle X-ray scattering (SAXS) and nuclear magnetic resonance (NMR) self-diffusion experiments. In vitro skin permeation experiments were performed with each prepared microemulsion using Franz type diffusion cells to correlate their present microstructure with their drug delivery to skin. Electrical conductivity increased with added water content. Consequently, the absence of a conductivity maximum as well as the NMR and SAXS data rather suggest O/W type microemulsions with spherical or rod-like microstructures. Skin permeation data revealed enhanced diffusion for Hex- and Sin-microemulsions if the shape of the structures was rather elongated than spherical implying that the shape of droplets had an essential impact on the skin permeation of flufenamic acid. Microemulsions are well known penetration enhancing delivery systems. Several properties are described that influence the transdermal delivery of active components. Therefore, this study aimed to characterize fluorosurfactant-based microemulsions and to assess the impact of formulation variables on the transdermal delivery of incorporated flufenamic acid. The microemulsion systems prepared in this study consisted of bistilled water, oleic acid, isopropanol as co-solvent, flufenamic acid as active ingredient and either Hexafor(TM)670 (Hex) or Chemguard S-550-100 (Sin) as fluorosurfactant. Characterization was performed by a combination of techniques including electrical conductivity measurements, small-angle X-ray scattering (SAXS) and nuclear magnetic resonance (NMR) self-diffusion experiments. In vitro skin permeation experiments were performed with each prepared microemulsion using Franz type diffusion cells to correlate their present microstructure with their drug delivery to skin. Electrical conductivity increased with added water content. Consequently, the absence of a conductivity maximum as well as the NMR and SAXS data rather suggest O/W type microemulsions with spherical or rod-like microstructures. Skin permeation data revealed enhanced diffusion for Hex- and Sin-microemulsions if the shape of the structures was rather elongated than spherical implying that the shape of droplets had an essential impact on the skin permeation of flufenamic acid.
Author	Peterlik, Herwig Kählig, Hanspeter Binder, Lisa Kwizda, Kristina Partyka-Jankowska, Ewa Valenta, Claudia Mahrhauser, Denise-Silvia
Author_xml	– sequence: 1 givenname: Denise-Silvia surname: Mahrhauser fullname: Mahrhauser, Denise-Silvia organization: Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences, Althanstraße 14, 1090 Vienna, Austria – sequence: 2 givenname: Hanspeter surname: Kählig fullname: Kählig, Hanspeter organization: Institute of Organic Chemistry, University of Vienna, Währingerstraße 38, 1090 Vienna, Austria – sequence: 3 givenname: Ewa surname: Partyka-Jankowska fullname: Partyka-Jankowska, Ewa organization: Faculty of Physics, University of Vienna, Boltzmanngasse 5, 1090 Vienna, Austria – sequence: 4 givenname: Herwig surname: Peterlik fullname: Peterlik, Herwig organization: Faculty of Physics, University of Vienna, Boltzmanngasse 5, 1090 Vienna, Austria – sequence: 5 givenname: Lisa surname: Binder fullname: Binder, Lisa organization: Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences, Althanstraße 14, 1090 Vienna, Austria – sequence: 6 givenname: Kristina surname: Kwizda fullname: Kwizda, Kristina organization: Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences, Althanstraße 14, 1090 Vienna, Austria – sequence: 7 givenname: Claudia surname: Valenta fullname: Valenta, Claudia email: claudia.valenta@univie.ac.at organization: Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences, Althanstraße 14, 1090 Vienna, Austria
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26022888$$D View this record in MEDLINE/PubMed
BookMark	eNqFkU1v1DAQhi1URLeFnwDKkUuWsb3-iDggVPFRqRIXOBvHmcAsibPYzkr99yTd7YVLpZEtW-8zo3nfK3YRp4iMveaw5cD1u_2W9offPo1bAVxtYS39jG24NbKWO6Mv2AaksbXiRl6yq5z3AKAFly_YpdAghLV2w37exiPmQr98oSlWU1-NFNKE4zzk9ePhlUuaQ5kTVj52FZVc0XjwoVSLIP-hWHU40BHT_cr3w9xj9AtY-UDdS_a890PGV-f7mv34_On7zdf67tuX25uPd3WQWpUaUSCAUL0SLQ-6a1shG7kcRvsgQIUGddhZaQUY45VptdmBV8p7K3psubxmb099D2n6Oy8ruZFywGHwEac5O64brppdY2GRvjlL53bEzh0SjT7du0dXFsH7k2DdPSfsXaDyYFBJngbHwa0ZuL07Z-DWDByspRda_Uc_DniK-3DicLHpSJhcDoQxYEcJQ3HdRE90-AdNYaUV
CitedBy_id	crossref_primary_10_3109_10837450_2016_1148722 crossref_primary_10_3390_ph13110329 crossref_primary_10_1016_j_jddst_2019_101245 crossref_primary_10_1016_j_molliq_2021_116361 crossref_primary_10_1016_j_molliq_2022_120405 crossref_primary_10_1016_j_colsurfb_2017_10_015 crossref_primary_10_1016_j_ejpb_2018_02_037 crossref_primary_10_1016_j_ijpharm_2017_06_050 crossref_primary_10_1007_s12032_025_02611_w crossref_primary_10_1016_j_colsurfb_2022_112474 crossref_primary_10_1016_j_molliq_2020_112742 crossref_primary_10_1080_10717544_2023_2234099 crossref_primary_10_1016_j_jddst_2017_08_002 crossref_primary_10_3390_molecules22091552 crossref_primary_10_1007_s11094_018_1858_6 crossref_primary_10_1016_j_colsurfb_2015_11_064 crossref_primary_10_1016_j_foodres_2023_112545 crossref_primary_10_1016_j_ijpharm_2017_11_041 crossref_primary_10_1080_02652048_2021_1957037 crossref_primary_10_1016_j_ejps_2023_106521 crossref_primary_10_1016_j_ijpharm_2016_07_043 crossref_primary_10_3390_pharmaceutics9040037
Cites_doi	10.1103/PhysRev.110.1 10.1159/000336787 10.1021/cm980756l 10.1006/jmra.1995.1176 10.1016/j.cocis.2012.07.002 10.1023/A:1022234305600 10.1016/j.ijpharm.2011.09.014 10.1016/j.ijpharm.2004.02.018 10.1016/S0927-7757(00)00744-5 10.1002/bip.1969.360080514 10.1081/DDC-100000125 10.1016/S0168-3659(00)00325-4 10.1007/s11095-011-0404-y 10.1016/j.ejpb.2014.04.019 10.1016/0022-3093(95)00021-6 10.1211/jpp.60.5.0003 10.1039/C2SM06903B 10.1016/j.addr.2012.09.032 10.1021/j100246a041 10.1016/j.fluid.2013.07.042 10.1016/j.ijpharm.2014.02.012 10.1016/S0169-409X(02)00116-3 10.1016/j.ijpharm.2009.10.052
ContentType	Journal Article
Copyright	2015 Elsevier B.V. Copyright © 2015 Elsevier B.V. All rights reserved.
Copyright_xml	– notice: 2015 Elsevier B.V. – notice: Copyright © 2015 Elsevier B.V. All rights reserved.
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7U8 7X8 C1K JXQ
DOI	10.1016/j.ijpharm.2015.05.056
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed TOXLINE MEDLINE - Academic Environmental Sciences and Pollution Management Toxline
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) TOXLINE MEDLINE - Academic Environmental Sciences and Pollution Management
DatabaseTitleList	MEDLINE TOXLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Pharmacy, Therapeutics, & Pharmacology
EISSN	1873-3476
EndPage	297
ExternalDocumentID	26022888 10_1016_j_ijpharm_2015_05_056 S0378517315004846
Genre	Research Support, Non-U.S. Gov't Journal Article
GrantInformation_xml	– fundername: Austrian Science Fund FWF grantid: P 24846
GroupedDBID	--- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 4.4 457 4G. 5GY 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AATCM AAXUO ABFNM ABFRF ABJNI ABMAC ABOCM ABYKQ ABZDS ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE AEBSH AEFWE AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC C45 CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA IHE J1W KOM M34 M41 MO0 N9A O-L O9- OAUVE OGGZJ OVD OZT P-8 P-9 P2P PC. Q38 RIG ROL RPZ SCC SDF SDG SDP SES SPCBC SSP SSZ T5K TEORI ~02 ~G- .GJ 29J 3O- 53G 9DU AAQXK AATTM AAXKI AAYWO AAYXX ABWVN ABXDB ACLOT ACRPL ACVFH ADCNI ADMUD ADNMO AEIPS AEUPX AFJKZ AFPUW AGQPQ AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP ASPBG AVWKF AZFZN CITATION EFKBS FEDTE FGOYB G-2 HMT HVGLF HZ~ R2- SEW SPT WUQ ZXP ~HD AGCQF AGRNS CGR CUY CVF ECM EIF NPM SSH 7U8 7X8 C1K JXQ
ID	FETCH-LOGICAL-c365t-ee2e0025f52b1c6dbb2393b2376ac205c9e6c48382077a57b6740a55aa82feb13
ISICitedReferencesCount	26
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000356836700033&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0378-5173
IngestDate	Mon Sep 29 06:00:08 EDT 2025 Mon Jul 21 05:57:33 EDT 2025 Sat Nov 29 01:40:11 EST 2025 Tue Nov 18 20:58:41 EST 2025 Fri Feb 23 02:34:46 EST 2024
IsPeerReviewed	true
IsScholarly	true
Issue	1-2
Keywords	Skin permeation studies NMR Electrical conductivity Microemulsion characterization ME Sin Hex SAXS
Language	English
License	Copyright © 2015 Elsevier B.V. All rights reserved.
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c365t-ee2e0025f52b1c6dbb2393b2376ac205c9e6c48382077a57b6740a55aa82feb13
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
PMID	26022888
PQID	1691594980
PQPubID	23479
PageCount	6
ParticipantIDs	proquest_miscellaneous_1691594980 pubmed_primary_26022888 crossref_citationtrail_10_1016_j_ijpharm_2015_05_056 crossref_primary_10_1016_j_ijpharm_2015_05_056 elsevier_sciencedirect_doi_10_1016_j_ijpharm_2015_05_056
PublicationCentury	2000
PublicationDate	2015-07-25
PublicationDateYYYYMMDD	2015-07-25
PublicationDate_xml	– month: 07 year: 2015 text: 2015-07-25 day: 25
PublicationDecade	2010
PublicationPlace	Netherlands
PublicationPlace_xml	– name: Netherlands
PublicationTitle	International journal of pharmaceutics
PublicationTitleAlternate	Int J Pharm
PublicationYear	2015
Publisher	Elsevier B.V
Publisher_xml	– name: Elsevier B.V
References	Zhang, Michniak-Kohn (bib0135) 2011; 1 Flory, Volkenstein (bib0040) 1969; 8 Emmerling, Petricevic, Beck, Wang, Scheller, Fricke (bib0020) 1995; 3 Nilsson, Lindman (bib0100) 1983; 23 Percus, Yevick (bib0105) 1958; 1 Cui, Fountain, Clark, Jay, Mumper (bib0015) 2003; 1 Kaushik, Costache, Michniak-Kohn (bib0065) 2010; 1 McClements (bib0090) 2012; 6 Hüsing, Schubert, Mezei, Fratzl, Riegel, Kiefer, Kohler, Mader (bib0060) 1999; 2 Acharya, Hartley (bib0005) 2012; 5 Kreilgaard (bib0070) 2002 Naoui, Bolzinger, Fenet, Pelletier, Valour, Kalfat, Chevalier (bib0095) 2011; 7 Kreilgaard, Pedersen, Jaroszewski (bib0075) 2000; 3 Podlogar, Gašperlin, Tomšič, Jamnik, Rogač (bib0110) 2004; 1 Guinier, Fournet, Walker, Pochan (bib0050) 1955 Fanun, Wachtel, Antalek, Aserin, Garti (bib0030) 2001; 1 Schwarz, Klang, Hoppel, Wolzt, Valenta (bib0115) 2012; 3 Hoeller, Klang, Valenta (bib0055) 2008; 5 Mahrhauser, Hoppel, Schöll, Binder, Kählig, Valenta (bib0085) 2014; 1 Lindman, Olsson, Söderman (bib0080) 1999 Szymczyk (bib0120) 2013 Ge, Lin, Lu, Li, He, Chen, Wu, Xu (bib0045) 2014; 1 Wu, Chen, Johnson (bib0130) 1995; 2 Williams, Barry (bib0125) 2012 Ezrahi, Aserin, Garti (bib0025) 1999 Feigin, Svergun (bib0035) 1987 Alany, Tucker, Davies, Rades (bib0010) 2001; 1 Alany (10.1016/j.ijpharm.2015.05.056_bib0010) 2001; 1 Acharya (10.1016/j.ijpharm.2015.05.056_bib0005) 2012; 5 Hüsing (10.1016/j.ijpharm.2015.05.056_bib0060) 1999; 2 Percus (10.1016/j.ijpharm.2015.05.056_bib0105) 1958; 1 Szymczyk (10.1016/j.ijpharm.2015.05.056_bib0120) 2013 Naoui (10.1016/j.ijpharm.2015.05.056_bib0095) 2011; 7 Podlogar (10.1016/j.ijpharm.2015.05.056_bib0110) 2004; 1 Zhang (10.1016/j.ijpharm.2015.05.056_bib0135) 2011; 1 Fanun (10.1016/j.ijpharm.2015.05.056_bib0030) 2001; 1 Ezrahi (10.1016/j.ijpharm.2015.05.056_bib0025) 1999 Kreilgaard (10.1016/j.ijpharm.2015.05.056_bib0070) 2002 Mahrhauser (10.1016/j.ijpharm.2015.05.056_bib0085) 2014; 1 Williams (10.1016/j.ijpharm.2015.05.056_bib0125) 2012 Lindman (10.1016/j.ijpharm.2015.05.056_bib0080) 1999 Feigin (10.1016/j.ijpharm.2015.05.056_bib0035) 1987 Hoeller (10.1016/j.ijpharm.2015.05.056_bib0055) 2008; 5 Emmerling (10.1016/j.ijpharm.2015.05.056_bib0020) 1995; 3 McClements (10.1016/j.ijpharm.2015.05.056_bib0090) 2012; 6 Kaushik (10.1016/j.ijpharm.2015.05.056_bib0065) 2010; 1 Nilsson (10.1016/j.ijpharm.2015.05.056_bib0100) 1983; 23 Schwarz (10.1016/j.ijpharm.2015.05.056_bib0115) 2012; 3 Kreilgaard (10.1016/j.ijpharm.2015.05.056_bib0075) 2000; 3 Wu (10.1016/j.ijpharm.2015.05.056_bib0130) 1995; 2 Cui (10.1016/j.ijpharm.2015.05.056_bib0015) 2003; 1 Ge (10.1016/j.ijpharm.2015.05.056_bib0045) 2014; 1 Flory (10.1016/j.ijpharm.2015.05.056_bib0040) 1969; 8 Guinier (10.1016/j.ijpharm.2015.05.056_bib0050) 1955
References_xml	– volume: 1 start-page: 115 year: 2004 end-page: 128 ident: bib0110 article-title: Structural characterisation of water-Tween 40 publication-title: Int. J.Pharm. – volume: 7 start-page: 1683 year: 2011 end-page: 1695 ident: bib0095 article-title: Microemulsion microstructure influences the skin delivery of an hydrophilic drug publication-title: Pharm. Res. – volume: 1 start-page: 42 year: 2010 end-page: 51 ident: bib0065 article-title: Percutaneous penetration modifiers and formulation effects publication-title: Int. J. Pharm. – start-page: 246 year: 2013 end-page: 255 ident: bib0120 article-title: Bulk and surface properties of the ternary mixtures of hydrocarbon and fluorocarbon surfactants publication-title: Fluid Phase Equilib. – volume: 8 start-page: 699 year: 1969 end-page: 700 ident: bib0040 article-title: Statistical mechanics of chain molecules publication-title: Biopolymers – year: 1955 ident: bib0050 article-title: Small-Angle Scattering of X-rays – volume: 1 start-page: 34 year: 2011 end-page: 44 ident: bib0135 article-title: Investigation of microemulsion microstructures and their relationship to transdermal permeation of model drugs: ketoprofen, lidocaine, and caffeine publication-title: Int. J. Pharm. – volume: 2 start-page: 260 year: 1995 end-page: 264 ident: bib0130 article-title: An improved diffusion-ordered spectroscopy experiment incorporating bipolar-gradient pulses publication-title: J. Magn. Reson., Ser. A – start-page: 185 year: 1999 end-page: 246 ident: bib0025 article-title: Handbook of Microemulsion Science and Technology – volume: 3 start-page: 240 year: 1995 end-page: 248 ident: bib0020 article-title: Relationship between optical transparency and nanostructural features of silica aerogels publication-title: J. Non-Cryst. Solids – volume: 1 start-page: 31 year: 2001 end-page: 38 ident: bib0010 article-title: Characterizing colloidal structures of pseudoternary phase diagrams formed by oil/water/amphiphile systems publication-title: Drug Dev. Ind. Pharm. – volume: 1 start-page: 120 year: 2014 end-page: 131 ident: bib0045 article-title: Percutaneous delivery of econazole using microemulsion as vehicle: formulation, evaluation and vesicle-skin interaction publication-title: Int. J. Pharm. – volume: 3 start-page: 421 year: 2000 end-page: 433 ident: bib0075 article-title: NMR characterisation and transdermal drug delivery potential of microemulsion systems publication-title: J. Controlled Release – volume: 1 start-page: 173 year: 2001 end-page: 186 ident: bib0030 article-title: A study of the microstructure of four-component sucrose ester microemulsions by SAXS and NMR publication-title: Colloids Surf. A – year: 1987 ident: bib0035 article-title: Structure analysis by small-angle X-ray and neutron scattering – start-page: 309 year: 1999 end-page: 356 ident: bib0080 article-title: Characterization of Microemulsions by NMR – volume: 3 start-page: 142 year: 2012 end-page: 149 ident: bib0115 article-title: Corneocyte quantification by NIR densitometry and UV–vis spectroscopy for human and porcine skin and the role of skin cleaning procedures publication-title: Skin Pharmacol. Physiol. – start-page: S77 year: 2002 end-page: S98 ident: bib0070 article-title: Influence of microemulsions on cutaneous drug delivery publication-title: Adv. Drug Deliv. Rev. – volume: 5 start-page: 274 year: 2012 end-page: 280 ident: bib0005 article-title: Progress in microemulsion characterization publication-title: Curr. Opin. Colloid Interface Sci. – volume: 2 start-page: 451 year: 1999 end-page: 457 ident: bib0060 article-title: Formation and structure of gel networks from Si (OEt) 4/(MeO) 3Si (CH2) 3NR′2 mixtures (NR′2 publication-title: Chem. Mater. – volume: 5 start-page: 587 year: 2008 end-page: 591 ident: bib0055 article-title: Skin-compatible lecithin drug delivery systems for fluconazole: effect of phosphatidylethanolamine and oleic acid on skin permeation publication-title: J. Pharm. Pharmacol. – volume: 6 start-page: 1719 year: 2012 end-page: 1729 ident: bib0090 article-title: Nanoemulsions versus microemulsions: terminology, differences, and similarities publication-title: Soft Matter – start-page: 128 year: 2012 end-page: 137 ident: bib0125 article-title: Penetration enhancers publication-title: Adv. Drug Delivery Rev. – volume: 1 start-page: 1 year: 1958 end-page: 13 ident: bib0105 article-title: Analysis of classical statistical mechanics by means of collective coordinates publication-title: Phys. Rev. – volume: 23 start-page: 4756 year: 1983 end-page: 4761 ident: bib0100 article-title: Water self-diffusion in nonionic surfactant solutions. Hydration and obstruction effects publication-title: J. Phys. Chem. – volume: 1 start-page: 34 year: 2014 end-page: 39 ident: bib0085 article-title: Simultaneous analysis of skin penetration of surfactant and active drug from fluorosurfactant-based microemulsions publication-title: Eur. J. Pharm. Biopharm. – volume: 1 start-page: 16 year: 2003 end-page: 23 ident: bib0015 article-title: Novel ethanol-in-fluorocarbon microemulsions for topical genetic immunization publication-title: Pharm. Res. – start-page: 309 year: 1999 ident: 10.1016/j.ijpharm.2015.05.056_bib0080 – volume: 1 start-page: 1 year: 1958 ident: 10.1016/j.ijpharm.2015.05.056_bib0105 article-title: Analysis of classical statistical mechanics by means of collective coordinates publication-title: Phys. Rev. doi: 10.1103/PhysRev.110.1 – volume: 3 start-page: 142 year: 2012 ident: 10.1016/j.ijpharm.2015.05.056_bib0115 article-title: Corneocyte quantification by NIR densitometry and UV–vis spectroscopy for human and porcine skin and the role of skin cleaning procedures publication-title: Skin Pharmacol. Physiol. doi: 10.1159/000336787 – volume: 2 start-page: 451 year: 1999 ident: 10.1016/j.ijpharm.2015.05.056_bib0060 article-title: Formation and structure of gel networks from Si (OEt) 4/(MeO) 3Si (CH2) 3NR′2 mixtures (NR′2=NH2 or NHCH2CH2NH2) publication-title: Chem. Mater. doi: 10.1021/cm980756l – volume: 2 start-page: 260 year: 1995 ident: 10.1016/j.ijpharm.2015.05.056_bib0130 article-title: An improved diffusion-ordered spectroscopy experiment incorporating bipolar-gradient pulses publication-title: J. Magn. Reson., Ser. A doi: 10.1006/jmra.1995.1176 – volume: 5 start-page: 274 year: 2012 ident: 10.1016/j.ijpharm.2015.05.056_bib0005 article-title: Progress in microemulsion characterization publication-title: Curr. Opin. Colloid Interface Sci. doi: 10.1016/j.cocis.2012.07.002 – volume: 1 start-page: 16 year: 2003 ident: 10.1016/j.ijpharm.2015.05.056_bib0015 article-title: Novel ethanol-in-fluorocarbon microemulsions for topical genetic immunization publication-title: Pharm. Res. doi: 10.1023/A:1022234305600 – year: 1955 ident: 10.1016/j.ijpharm.2015.05.056_bib0050 – volume: 1 start-page: 34 year: 2011 ident: 10.1016/j.ijpharm.2015.05.056_bib0135 article-title: Investigation of microemulsion microstructures and their relationship to transdermal permeation of model drugs: ketoprofen, lidocaine, and caffeine publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2011.09.014 – volume: 1 start-page: 115 year: 2004 ident: 10.1016/j.ijpharm.2015.05.056_bib0110 article-title: Structural characterisation of water-Tween 40®/Imwitor 308®-isopropyl myristate microemulsions using different experimental methods publication-title: Int. J.Pharm. doi: 10.1016/j.ijpharm.2004.02.018 – year: 1987 ident: 10.1016/j.ijpharm.2015.05.056_bib0035 – volume: 1 start-page: 173 year: 2001 ident: 10.1016/j.ijpharm.2015.05.056_bib0030 article-title: A study of the microstructure of four-component sucrose ester microemulsions by SAXS and NMR publication-title: Colloids Surf. A doi: 10.1016/S0927-7757(00)00744-5 – volume: 8 start-page: 699 year: 1969 ident: 10.1016/j.ijpharm.2015.05.056_bib0040 article-title: Statistical mechanics of chain molecules publication-title: Biopolymers doi: 10.1002/bip.1969.360080514 – volume: 1 start-page: 31 year: 2001 ident: 10.1016/j.ijpharm.2015.05.056_bib0010 article-title: Characterizing colloidal structures of pseudoternary phase diagrams formed by oil/water/amphiphile systems publication-title: Drug Dev. Ind. Pharm. doi: 10.1081/DDC-100000125 – volume: 3 start-page: 421 year: 2000 ident: 10.1016/j.ijpharm.2015.05.056_bib0075 article-title: NMR characterisation and transdermal drug delivery potential of microemulsion systems publication-title: J. Controlled Release doi: 10.1016/S0168-3659(00)00325-4 – volume: 7 start-page: 1683 year: 2011 ident: 10.1016/j.ijpharm.2015.05.056_bib0095 article-title: Microemulsion microstructure influences the skin delivery of an hydrophilic drug publication-title: Pharm. Res. doi: 10.1007/s11095-011-0404-y – volume: 1 start-page: 34 year: 2014 ident: 10.1016/j.ijpharm.2015.05.056_bib0085 article-title: Simultaneous analysis of skin penetration of surfactant and active drug from fluorosurfactant-based microemulsions publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2014.04.019 – start-page: 185 year: 1999 ident: 10.1016/j.ijpharm.2015.05.056_bib0025 article-title: Handbook of Microemulsion Science and Technology – volume: 3 start-page: 240 year: 1995 ident: 10.1016/j.ijpharm.2015.05.056_bib0020 article-title: Relationship between optical transparency and nanostructural features of silica aerogels publication-title: J. Non-Cryst. Solids doi: 10.1016/0022-3093(95)00021-6 – volume: 5 start-page: 587 year: 2008 ident: 10.1016/j.ijpharm.2015.05.056_bib0055 article-title: Skin-compatible lecithin drug delivery systems for fluconazole: effect of phosphatidylethanolamine and oleic acid on skin permeation publication-title: J. Pharm. Pharmacol. doi: 10.1211/jpp.60.5.0003 – volume: 6 start-page: 1719 year: 2012 ident: 10.1016/j.ijpharm.2015.05.056_bib0090 article-title: Nanoemulsions versus microemulsions: terminology, differences, and similarities publication-title: Soft Matter doi: 10.1039/C2SM06903B – start-page: 128 year: 2012 ident: 10.1016/j.ijpharm.2015.05.056_bib0125 article-title: Penetration enhancers publication-title: Adv. Drug Delivery Rev. doi: 10.1016/j.addr.2012.09.032 – volume: 23 start-page: 4756 year: 1983 ident: 10.1016/j.ijpharm.2015.05.056_bib0100 article-title: Water self-diffusion in nonionic surfactant solutions. Hydration and obstruction effects publication-title: J. Phys. Chem. doi: 10.1021/j100246a041 – start-page: 246 year: 2013 ident: 10.1016/j.ijpharm.2015.05.056_bib0120 article-title: Bulk and surface properties of the ternary mixtures of hydrocarbon and fluorocarbon surfactants publication-title: Fluid Phase Equilib. doi: 10.1016/j.fluid.2013.07.042 – volume: 1 start-page: 120 year: 2014 ident: 10.1016/j.ijpharm.2015.05.056_bib0045 article-title: Percutaneous delivery of econazole using microemulsion as vehicle: formulation, evaluation and vesicle-skin interaction publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2014.02.012 – start-page: S77 year: 2002 ident: 10.1016/j.ijpharm.2015.05.056_bib0070 article-title: Influence of microemulsions on cutaneous drug delivery publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/S0169-409X(02)00116-3 – volume: 1 start-page: 42 year: 2010 ident: 10.1016/j.ijpharm.2015.05.056_bib0065 article-title: Percutaneous penetration modifiers and formulation effects publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2009.10.052
SSID	ssj0006213
Score	2.2938735
Snippet	[Display omitted] Microemulsions are well known penetration enhancing delivery systems. Several properties are described that influence the transdermal... Microemulsions are well known penetration enhancing delivery systems. Several properties are described that influence the transdermal delivery of active...
SourceID	proquest pubmed crossref elsevier
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	292
SubjectTerms	Administration, Cutaneous Chemistry, Pharmaceutical - methods Drug Delivery Systems - methods Electrical conductivity Emulsions - administration & dosage Emulsions - chemistry Flufenamic Acid - administration & dosage Flufenamic Acid - chemistry Microemulsion characterization NMR Permeability SAXS Scattering, Small Angle Skin - metabolism Skin Absorption Skin permeation studies Solvents - chemistry Surface-Active Agents - chemistry Water - chemistry X-Ray Diffraction - methods
Title	Investigation of microemulsion microstructure and its impact on skin delivery of flufenamic acid
URI	https://dx.doi.org/10.1016/j.ijpharm.2015.05.056 https://www.ncbi.nlm.nih.gov/pubmed/26022888 https://www.proquest.com/docview/1691594980
Volume	490
WOSCitedRecordID	wos000356836700033&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1873-3476 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0006213 issn: 0378-5173 databaseCode: AIEXJ dateStart: 19950102 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3bbtpAEF0R0oe-VL2XXqKtVOUlMTVm114_RhVVmrYRUqjEm7t21sHgGIQDhL_sJ3XGu7ahaZS2UiVkgYXxZQ6zZ2dnzhDyzkWYwNTH4sBFLRa7ChcJQ8sOO0zZ577vRYVk_hfv9FQMh36_0fhR1sIsUy_LxPW1P_uvpoZ9YGwsnf0Lc1c_CjvgPRgdtmB22P6R4TeUMzQXvMScO3W5SDEwpj9p1djNtYOyWjI7yCdFgmyKCRvF8nucLmJV9K0_kFGy1dhzO564oUIxG9Wh8oq1f5Wj-UhiWER7uizJlXWWpMukGhs-Fwv3bJQmhQs6RuX1zQziPtzweiKtE5lNpqt8UlDf3krWHh4zVJOJHlHnq-RiM6zR4Rgv1SXQOtZ2o95G13jBnJd3dPOTttIuW3hdq8t0F5nSpzPdg7QEr6mwND5aN98zw72j04NvjCQ6qDFuJ-PiiWESIC80Xvkvyt0FFzjDK8MLA34NPpG5O2TX8bgvmmT36FNveFKxA9cxLbvNndRVZe9_e7Lb-NJt86GCFw0ekgdmQkOPNBAfkYbKHpP9vrb_-pAO6gK__JDu036tlb5-Qr5voZVOY7qFVrqNVgpopYBWqtFK4QuIVlqiFY-v0UoRrU_Jt4-9wYdjyzT9sKKuy68spRyFRDzmTtiJ3PMwRJG-EJO3UE2UR75yIya6wFw9T3IvdD1mS86lFE4MxKP7jDSzaaZeEOo6uAwPc2Zhh4zZUSiFjKNQKRZHzFdhi7Dy0QaRUcTHxixpUKY-jgNjkQAtEtj4clukXR0205Iwdx0gSrsFhtdqvhoA2O469G1p5wD8Pi7myUxNF3mAIlfcZ76wW-S5BkB1NY6LqlZCvPz3E78i9-t_5WvSBEOrN-RetLxK8vke2fGGYs9A-yfsIOUG
linkProvider	Elsevier
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Investigation+of+microemulsion+microstructure+and+its+impact+on+skin+delivery+of+flufenamic+acid&rft.jtitle=International+journal+of+pharmaceutics&rft.au=Mahrhauser%2C+Denise-Silvia&rft.au=K%C3%A4hlig%2C+Hanspeter&rft.au=Partyka-Jankowska%2C+Ewa&rft.au=Peterlik%2C+Herwig&rft.date=2015-07-25&rft.pub=Elsevier+B.V&rft.issn=0378-5173&rft.eissn=1873-3476&rft.volume=490&rft.issue=1-2&rft.spage=292&rft.epage=297&rft_id=info:doi/10.1016%2Fj.ijpharm.2015.05.056&rft.externalDocID=S0378517315004846
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0378-5173&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0378-5173&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0378-5173&client=summon