Investigation of microemulsion microstructure and its impact on skin delivery of flufenamic acid

[Display omitted] Microemulsions are well known penetration enhancing delivery systems. Several properties are described that influence the transdermal delivery of active components. Therefore, this study aimed to characterize fluorosurfactant-based microemulsions and to assess the impact of formula...

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Vydané v:International journal of pharmaceutics Ročník 490; číslo 1-2; s. 292 - 297
Hlavní autori: Mahrhauser, Denise-Silvia, Kählig, Hanspeter, Partyka-Jankowska, Ewa, Peterlik, Herwig, Binder, Lisa, Kwizda, Kristina, Valenta, Claudia
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Netherlands Elsevier B.V 25.07.2015
Predmet:
Administration, Cutaneous
Chemistry, Pharmaceutical - methods
Drug Delivery Systems - methods
Electrical conductivity
Emulsions - administration & dosage
Emulsions - chemistry
Flufenamic Acid - administration & dosage
Flufenamic Acid - chemistry
Microemulsion characterization
NMR
Permeability
SAXS
Scattering, Small Angle
Skin - metabolism
Skin Absorption
Skin permeation studies
Solvents - chemistry
Surface-Active Agents - chemistry
Water - chemistry
X-Ray Diffraction - methods
Skin permeation studies
NMR
Electrical conductivity
Microemulsion characterization
ME
Sin
Hex
SAXS
ISSN:0378-5173, 1873-3476
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Shrnutí:[Display omitted] Microemulsions are well known penetration enhancing delivery systems. Several properties are described that influence the transdermal delivery of active components. Therefore, this study aimed to characterize fluorosurfactant-based microemulsions and to assess the impact of formulation variables on the transdermal delivery of incorporated flufenamic acid. The microemulsion systems prepared in this study consisted of bistilled water, oleic acid, isopropanol as co-solvent, flufenamic acid as active ingredient and either HexaforTM670 (Hex) or Chemguard S-550-100 (Sin) as fluorosurfactant. Characterization was performed by a combination of techniques including electrical conductivity measurements, small-angle X-ray scattering (SAXS) and nuclear magnetic resonance (NMR) self-diffusion experiments. In vitro skin permeation experiments were performed with each prepared microemulsion using Franz type diffusion cells to correlate their present microstructure with their drug delivery to skin. Electrical conductivity increased with added water content. Consequently, the absence of a conductivity maximum as well as the NMR and SAXS data rather suggest O/W type microemulsions with spherical or rod-like microstructures. Skin permeation data revealed enhanced diffusion for Hex- and Sin-microemulsions if the shape of the structures was rather elongated than spherical implying that the shape of droplets had an essential impact on the skin permeation of flufenamic acid.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2015.05.056