Shrimp Plasma MANF Works as an Invertebrate Anti-Inflammatory Factor via a Conserved Receptor Tyrosine Phosphatase

For a long time, how anti-inflammatory factors evolved was largely unknown. In this study, we chose a marine invertebrate, , as a model and identified that shrimp mesencephalic astrocyte-derived neurotrophic factor (MANF) was an LPS-induced plasma protein, which exerted its anti-inflammatory roles o...

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Vydáno v:	The Journal of immunology (1950) Ročník 208; číslo 5; s. 1214
Hlavní autoři:	Luo, Kaiwen, Chen, Yaohui, Wang, Fan
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.03.2022
Témata:	Amino Acid Sequence Animals Apoptosis - immunology Cell Line Endoplasmic Reticulum Stress - physiology Extracellular Signal-Regulated MAP Kinases - metabolism HEK293 Cells Humans Inflammation - pathology Lipopolysaccharides - metabolism MAP Kinase Signaling System - physiology Nerve Growth Factors - metabolism Neurons - physiology Penaeidae - immunology Phosphorylation - physiology Receptor Protein-Tyrosine Kinases - metabolism Sequence Alignment
ISSN:	1550-6606, 1550-6606
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Abstract	For a long time, how anti-inflammatory factors evolved was largely unknown. In this study, we chose a marine invertebrate, , as a model and identified that shrimp mesencephalic astrocyte-derived neurotrophic factor (MANF) was an LPS-induced plasma protein, which exerted its anti-inflammatory roles on shrimp hemocytes by suppressing ERK phosphorylation and Dorsal expression. In addition, we demonstrated that shrimp MANF could be associated with a receptor protein tyrosine phosphatase (RPTP) to mediate negative regulation of ERK activation and Dorsal expression. More interestingly, shrimp RPTP-S overexpression in 293T cells could switch shrimp and human MANF-mediated ERK pathway activation to inhibition. In general, our results indicate that this conserved RPTP is the key component for extracellular MANF-mediated ERK pathway inhibition, which gives a possible explanation about why this neurotropic factor could both protect neuron cells from apoptosis and inhibit immune cell M1 activation in various species.
AbstractList	For a long time, how anti-inflammatory factors evolved was largely unknown. In this study, we chose a marine invertebrate, Litopenaeus vannamei, as a model and identified that shrimp mesencephalic astrocyte-derived neurotrophic factor (MANF) was an LPS-induced plasma protein, which exerted its anti-inflammatory roles on shrimp hemocytes by suppressing ERK phosphorylation and Dorsal expression. In addition, we demonstrated that shrimp MANF could be associated with a receptor protein tyrosine phosphatase (RPTP) to mediate negative regulation of ERK activation and Dorsal expression. More interestingly, shrimp RPTP-S overexpression in 293T cells could switch shrimp and human MANF-mediated ERK pathway activation to inhibition. In general, our results indicate that this conserved RPTP is the key component for extracellular MANF-mediated ERK pathway inhibition, which gives a possible explanation about why this neurotropic factor could both protect neuron cells from apoptosis and inhibit immune cell M1 activation in various species.For a long time, how anti-inflammatory factors evolved was largely unknown. In this study, we chose a marine invertebrate, Litopenaeus vannamei, as a model and identified that shrimp mesencephalic astrocyte-derived neurotrophic factor (MANF) was an LPS-induced plasma protein, which exerted its anti-inflammatory roles on shrimp hemocytes by suppressing ERK phosphorylation and Dorsal expression. In addition, we demonstrated that shrimp MANF could be associated with a receptor protein tyrosine phosphatase (RPTP) to mediate negative regulation of ERK activation and Dorsal expression. More interestingly, shrimp RPTP-S overexpression in 293T cells could switch shrimp and human MANF-mediated ERK pathway activation to inhibition. In general, our results indicate that this conserved RPTP is the key component for extracellular MANF-mediated ERK pathway inhibition, which gives a possible explanation about why this neurotropic factor could both protect neuron cells from apoptosis and inhibit immune cell M1 activation in various species. For a long time, how anti-inflammatory factors evolved was largely unknown. In this study, we chose a marine invertebrate, , as a model and identified that shrimp mesencephalic astrocyte-derived neurotrophic factor (MANF) was an LPS-induced plasma protein, which exerted its anti-inflammatory roles on shrimp hemocytes by suppressing ERK phosphorylation and Dorsal expression. In addition, we demonstrated that shrimp MANF could be associated with a receptor protein tyrosine phosphatase (RPTP) to mediate negative regulation of ERK activation and Dorsal expression. More interestingly, shrimp RPTP-S overexpression in 293T cells could switch shrimp and human MANF-mediated ERK pathway activation to inhibition. In general, our results indicate that this conserved RPTP is the key component for extracellular MANF-mediated ERK pathway inhibition, which gives a possible explanation about why this neurotropic factor could both protect neuron cells from apoptosis and inhibit immune cell M1 activation in various species.
Author	Wang, Fan Chen, Yaohui Luo, Kaiwen
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SubjectTerms	Amino Acid Sequence Animals Apoptosis - immunology Cell Line Endoplasmic Reticulum Stress - physiology Extracellular Signal-Regulated MAP Kinases - metabolism HEK293 Cells Humans Inflammation - pathology Lipopolysaccharides - metabolism MAP Kinase Signaling System - physiology Nerve Growth Factors - metabolism Neurons - physiology Penaeidae - immunology Phosphorylation - physiology Receptor Protein-Tyrosine Kinases - metabolism Sequence Alignment
Title	Shrimp Plasma MANF Works as an Invertebrate Anti-Inflammatory Factor via a Conserved Receptor Tyrosine Phosphatase
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