Experimental Trypanosoma evansi infection induces pain along with oxidative stress, prevented by COX-2 inhibition

[Display omitted] •Nonsteroidal anti-inflammatory drugs prevent inflammation, pain and oxidative stress triggered by T. evansi rodent infection.•The inflammation provoked by T. evansi infection in probably mediated by cyclooxygenase-2 and its molecular mediators.•Mice infected by T. evansi show high...

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Vydáno v:Experimental parasitology Ročník 247; s. 108477
Hlavní autoři: Cipriani, Daniel Sérgio, Borges, Gabriela Kaiser, Povaluk, Ana Paula, Stipp, Maria Carolina, Casagrande, Renata Assis, Vogel, Carla Ivane Ganz, Miletti, Luiz Claudio, Bastos-Pereira, Amanda Leite
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 01.04.2023
Témata:
Cyclooxygenase 2
Humans
Oxidative Stress
Pain
Trypanosoma
Trypanosomiasis - drug therapy
ISSN:0014-4894, 1090-2449, 1090-2449
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Shrnutí:[Display omitted] •Nonsteroidal anti-inflammatory drugs prevent inflammation, pain and oxidative stress triggered by T. evansi rodent infection.•The inflammation provoked by T. evansi infection in probably mediated by cyclooxygenase-2 and its molecular mediators.•Mice infected by T. evansi show higher presence of vacuolar degeneration of hepatocytes related to oxidative stress damage.•T.evansi infection leads to oxidative stress, affecting both enzymatic and non-enzymatic host protective systems.
Bibliografie:ObjectType-Article-1
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content type line 23
ISSN:0014-4894
1090-2449
1090-2449
DOI:10.1016/j.exppara.2023.108477