Experimental Trypanosoma evansi infection induces pain along with oxidative stress, prevented by COX-2 inhibition

[Display omitted] •Nonsteroidal anti-inflammatory drugs prevent inflammation, pain and oxidative stress triggered by T. evansi rodent infection.•The inflammation provoked by T. evansi infection in probably mediated by cyclooxygenase-2 and its molecular mediators.•Mice infected by T. evansi show high...

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Published in:Experimental parasitology Vol. 247; p. 108477
Main Authors: Cipriani, Daniel Sérgio, Borges, Gabriela Kaiser, Povaluk, Ana Paula, Stipp, Maria Carolina, Casagrande, Renata Assis, Vogel, Carla Ivane Ganz, Miletti, Luiz Claudio, Bastos-Pereira, Amanda Leite
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.04.2023
Subjects:
Cyclooxygenase 2
Humans
Oxidative Stress
Pain
Trypanosoma
Trypanosomiasis - drug therapy
ISSN:0014-4894, 1090-2449, 1090-2449
Online Access:Get full text
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Summary:[Display omitted] •Nonsteroidal anti-inflammatory drugs prevent inflammation, pain and oxidative stress triggered by T. evansi rodent infection.•The inflammation provoked by T. evansi infection in probably mediated by cyclooxygenase-2 and its molecular mediators.•Mice infected by T. evansi show higher presence of vacuolar degeneration of hepatocytes related to oxidative stress damage.•T.evansi infection leads to oxidative stress, affecting both enzymatic and non-enzymatic host protective systems.
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ISSN:0014-4894
1090-2449
1090-2449
DOI:10.1016/j.exppara.2023.108477