Vascular endothelial‐cadherin stimulates syndecan‐1‐coupled insulin‐like growth factor‐1 receptor and cross‐talk between αVβ3 integrin and vascular endothelial growth factor receptor 2 at the onset of endothelial cell dissemination during angiogenesis

Vascular endothelial growth factor (VEGF)‐stimulated angiogenesis depends on a cross‐talk mechanism involving VEGF receptor 2 (VEGFR2), vascular endothelial (VE)‐cadherin and the αVβ3 integrin. Because we have shown that αVβ3 integrin activation is dependent on its incorporation, along with the insu...

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Bibliographic Details
Published in:	The FEBS journal Vol. 280; no. 10; pp. 2194 - 2206
Main Authors:	Rapraeger, Alan C., Ell, Brian J., Roy, Madhuchhanda, Li, Xuehui, Morrison, Orrianne R., Thomas, Grant M., Beauvais, DeannaLee M.
Format:	Journal Article
Language:	English
Published:	England 01.05.2013
Subjects:	Animals Antibodies - metabolism Antigens, CD - metabolism Aorta - drug effects Aorta - metabolism aortic ring blocking antibodies Cadherins - antagonists & inhibitors Cadherins - metabolism Cell Adhesion Cell Movement Cells, Cultured Collagen - metabolism Endothelial Cells - drug effects Endothelial Cells - metabolism Human Umbilical Vein Endothelial Cells Humans Integrin alphaVbeta3 - metabolism Mice Neovascularization, Physiologic - drug effects Peptides - pharmacology Phosphorylation Protein Binding Protein Interaction Mapping Receptor Cross-Talk Receptors, Somatomedin - antagonists & inhibitors Receptors, Somatomedin - metabolism scratch wound Syndecan-1 - metabolism synstatin Ternary Complex Factors - metabolism Vascular Endothelial Growth Factor A - pharmacology Vascular Endothelial Growth Factor Receptor-2 - metabolism
ISSN:	1742-464X, 1742-4658, 1742-4658
Online Access:	Get full text
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