Expression of metallothionein isoform 3 (MT-3) determines the choice between apoptotic or necrotic cell death in Cd+2-exposed human proximal tubule cells

This laboratory has shown that the third isoform of metallothionein (MT-3) is expressed in the human kidney in situ, including the cells of the proximal tubule. A subsequent analysis of MT-3 expression in cell cultures derived from the human proximal tubule (HPT) demonstrated that mortal HPT cells e...

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Bibliographic Details
Published in:	Toxicological sciences Vol. 80; no. 2; p. 358
Main Authors:	Somji, Seema, Garrett, Scott H, Sens, Mary Ann, Gurel, Volkan, Sens, Donald A
Format:	Journal Article
Language:	English
Published:	United States 01.08.2004
Subjects:	Apoptosis - drug effects Cadmium - toxicity Caspase 3 Caspases - metabolism Cell Death - drug effects Cell Line Cell Survival - drug effects DNA - genetics Fluorescent Dyes Humans Indoles Isomerism Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - pathology L-Lactate Dehydrogenase - metabolism Necrosis Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Reverse Transcriptase Polymerase Chain Reaction Transfection
ISSN:	1096-6080
Online Access:	Get more information
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