Hearing loss in patients on treatment for drug-resistant tuberculosis

The treatment of drug-resistant (DR)-tuberculosis (TB) necessitates the use of second-line injectable anti-TB drugs which are associated with hearing loss. Hearing loss affects communication and the development of language and social skills in children. This review describes the pathophysiology of h...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The European respiratory journal Jg. 40; H. 5; S. 1277
Hauptverfasser: Seddon, James A, Godfrey-Faussett, Peter, Jacobs, Kayleen, Ebrahim, Adam, Hesseling, Anneke C, Schaaf, H Simon
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England 01.11.2012
Schlagworte:
Antitubercular Agents - adverse effects
Antitubercular Agents - therapeutic use
Hearing Loss - chemically induced
Hearing Loss - diagnosis
Hearing Tests
Humans
Tuberculosis, Multidrug-Resistant - drug therapy
ISSN:1399-3003, 1399-3003
Online-Zugang:Weitere Angaben
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The treatment of drug-resistant (DR)-tuberculosis (TB) necessitates the use of second-line injectable anti-TB drugs which are associated with hearing loss. Hearing loss affects communication and the development of language and social skills in children. This review describes the pathophysiology of hearing loss and the testing methodologies that can be employed. It is the first paper to systematically review the literature regarding hearing loss in those treated for DR-TB. In the studies identified, the methodology used to test for and to classify hearing loss is inconsistent and children and those with HIV are poorly represented. This review describes existing guidelines and suggests management strategies when hearing loss is found. It describes the challenges of testing hearing in the developing world contexts where the majority of patients with DR-TB are treated. Finally it makes the recommendation that a standardised testing methodology and classification system should be used.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1399-3003
1399-3003
DOI:10.1183/09031936.00044812