Significant association of hyperandrogenism and insulin resistance with the epigenetic alterations in PPARG1 gene in granulosa cells of PCOS females

Background Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine and metabolic disorders, affecting approximately 15% of females. This syndrome is characterized by its remarkable heterogeneity, and epigenetic factors may contribute to its development. Since the PPARG gene is crucia...

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Bibliographic Details
Published in:	Egyptian Journal of Medical Human Genetics Vol. 26; no. 1; pp. 99 - 11
Main Authors:	Dashti, Zahra, Razban, Vahid, Fallahi, Jafar, Parsanezhad, Mohammad ebrahim, Mehdinejadiani, Shayesteh, Ghasemi, Nasrin
Format:	Journal Article
Language:	English
Published:	Cairo Springer 01.12.2025 Springer Nature B.V SpringerOpen
Subjects:	Androgens Bisulfite Body fat Development and progression Dextrose Diabetes DNA methylation Down-regulation Epigenetic inheritance Epigenetics Females Follicular fluid Gene expression Genes Glucose Glucose metabolism Granulosa cells Hyperandrogenism Hyperinsulinemia Infertility Insulin resistance Lipid metabolism Lipids Menstruation Metabolic disorders Metabolic syndrome Methylation Obesity Ovaries Ovulation PCO Polycystic ovary syndrome Polymerase chain reaction PPARG1 Stein-Leventhal syndrome Testosterone Thermal cycling Type 2 diabetes Ultrasonic imaging Iran
ISSN:	1110-8630, 2090-2441
Online Access:	Get full text
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