Protective effects of geraniol in a male rat model of Alzheimer's disease: A behavioral, biochemical, and histological study

Alzheimer's disease (AD) as a neurodegenerative disease can cause behavioral impairments due to oxidative stress. Aging and oxidative conditions are some AD risk factors. We assessed the influence of geraniol (GR), an acyclic monoterpene alcohol, on behavioral functions, hippocampal oxidative s...

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Veröffentlicht in:Journal of Alzheimer's disease Jg. 102; H. 3; S. 646
Hauptverfasser: Bagheri, Shokufeh, Rashno, Masome, Salehi, Iraj, Karimi, Seyed Asaad, Raoufi, Safoura, Komaki, Alireza
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.12.2024
Schlagworte:
Acyclic Monoterpenes - pharmacology
Alzheimer Disease - drug therapy
Alzheimer Disease - pathology
Amyloid beta-Peptides - metabolism
Animals
Behavior, Animal - drug effects
Disease Models, Animal
Hippocampus - drug effects
Hippocampus - pathology
Male
Maze Learning - drug effects
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Oxidative Stress - drug effects
Peptide Fragments
Rats
Rats, Wistar
Recognition, Psychology - drug effects
Terpenes - pharmacology
Terpenes - therapeutic use
geraniol
learning and memory
rat
Alzheimer's disease
oxidative stress
ISSN:1875-8908, 1875-8908
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Zusammenfassung:Alzheimer's disease (AD) as a neurodegenerative disease can cause behavioral impairments due to oxidative stress. Aging and oxidative conditions are some AD risk factors. We assessed the influence of geraniol (GR), an acyclic monoterpene alcohol, on behavioral functions, hippocampal oxidative status, and histological alterations in AD rats induced by amyloid-β (Aβ). Male Wistar rats (n = 70) were randomly allocated to the control, sham, AD, control-GR (100 mg/kg; per oral: P.O.), AD-GR (100 mg/kg; P.O.; treatment), GR-AD (100 mg/kg; P.O.; pretreatment), and GR-AD-GR (100 mg/kg; P.O.; pretreatment + treatment) groups. GR administration was done for four continuous weeks. After treatments, novel object recognition (NOR) and Morris water maze (MWM) tests assessed the animals' behavior. Then, hippocampal specimens were collected for biochemical assessment. Finally, the number of intact neurons was identified in the hippocampus using hematoxylin and eosin staining. Aβ microinjection increased learning and memory deficits in both NOR and MWM tests, oxidative stress status, and neuronal loss. Oral GR administration improved behavioral deficits and reduced oxidative stress status and neuronal loss in the Aβ-infused animals. GR ameliorates behavioral impairments through a decrease in neuronal degeneration and oxidative stress.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1875-8908
1875-8908
DOI:10.1177/13872877241290695