Quantification of blood flow in brain tumors: comparison of arterial spin labeling and dynamic susceptibility-weighted contrast-enhanced MR imaging

To implement an arterial spin labeling technique that is feasible in routine examinations and to test the method and compare it with dynamic susceptibility-weighted contrast material-enhanced magnetic resonance (MR) imaging for evaluation of tumor blood flow (TBF) in patients with brain tumors. Thir...

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Vydáno v:Radiology Ročník 228; číslo 2; s. 523
Hlavní autoři: Warmuth, Carsten, Gunther, Matthias, Zimmer, Claus
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.08.2003
Témata:
Adolescent
Adult
Aged
Brain Neoplasms - blood supply
Brain Neoplasms - pathology
Cerebrovascular Circulation - physiology
Child
Contrast Media
Female
Gadolinium DTPA
Glioma - blood supply
Glioma - pathology
Humans
Image Processing, Computer-Assisted
Linear Models
Magnetic Resonance Imaging - methods
Male
Microcirculation
Middle Aged
Perfusion
Spin Labels
Statistics, Nonparametric
ISSN:0033-8419
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Popis
Shrnutí:To implement an arterial spin labeling technique that is feasible in routine examinations and to test the method and compare it with dynamic susceptibility-weighted contrast material-enhanced magnetic resonance (MR) imaging for evaluation of tumor blood flow (TBF) in patients with brain tumors. Thirty-six patients with histologically proven brain tumors were examined at 1.5 T. A second version of quantitative imaging of perfusion by using a single subtraction with addition of thin-section periodic saturation after inversion and a time delay (Q2TIPS) technique of pulsed arterial spin labeling in the multisection mode was implemented. After arterial spin labeling, a combined T2- and T2*-weighted first-pass bolus perfusion study (gadopentetate dimeglumine, 0.2 mmol/kg) was performed by using a double-echo echo-planar imaging sequence. In regions of interest, maps of absolute and relative cerebral blood flow were computed and analyzed with arterial spin labeling and dynamic susceptibility-weighted contrast-enhanced MR imaging, respectively. Both techniques yielded the highest perfusion values in imaging of glioblastomas and the lowest values in imaging of two low-grade gliomas that both showed strong gadopentetate dimeglumine enhancement. There was a close linear correlation between dynamic susceptibility-weighted contrast-enhanced MR imaging and arterial spin labeling in the tumor region of interest (linear regression coefficient, R = 0.83; P <.005). Blood flow is underestimated with arterial spin labeling at low flow rates. High- and low-grade gliomas can be distinguished at the same level of significance with both methods. Absolute TBF is less important for tumor grading than is the ratio of TBF to age-dependent mean brain perfusion. Arterial spin labeling is a suitable method for assessment of microvascular perfusion and allows distinction between high- and low-grade gliomas.
Bibliografie:ObjectType-Article-2
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ISSN:0033-8419
DOI:10.1148/radiol.2282020409