CXCL13 and CXCR5 are upregulated in PCOS mice ovaries but downregulated following metformin administration

Polycystic ovary syndrome (PCOS) is becoming a common pathology among women, yet its pathogenesis remains enigmatic. The chemokine C-X-C motif ligand 13 (CXCL13) and its receptor type 5 (CXCR5) regulate inflammatory responses but their roles in PCOS remain unknown. Metformin is commonly administered...

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Vydáno v:	Molecular and cellular endocrinology Ročník 556; s. 111730
Hlavní autoři:	Ullah, Amin, Pervaz, Sadaf, Adu-Gyamfi, Enoch Appiah, Czika, Armin, Guo, Man, Wang, Mei-Jiao, Wang, Ying-Xiong
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Elsevier B.V 01.10.2022
Témata:	CXCL13 CXCR5 endocrinology Extracellular-signaling-related kinase Inflammation mechanism of action Metformin pathogenesis Polycystic ovarian syndrome polycystic ovary syndrome therapeutics CXCR5 Polycystic ovarian syndrome Inflammation Metformin Extracellular-signaling-related kinase CXCL13
ISSN:	0303-7207, 1872-8057, 1872-8057
On-line přístup:	Získat plný text
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