Mechanisms of vitamin D action in skeletal muscle

Vitamin D receptor expression and associated function have been reported in various muscle models, including C 2 C 12 , L6 cell lines and primary human skeletal muscle cells. It is believed that 1,25-hydroxyvitamin D 3 (1,25(OH) 2 D 3 ), the active form of vitamin D, has a direct regulatory role in...

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Vydané v:	Nutrition research reviews Ročník 32; číslo 2; s. 192 - 204
Hlavní autori:	Montenegro, Karina Romeu, Cruzat, Vinicius, Carlessi, Rodrigo, Newsholme, Philip
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Cambridge University Press 01.12.2019
Predmet:	Atrophy Bioavailability Bone density Calciferol Calcitriol calcitriol receptors Cardiovascular disease cell communication Cell culture Cell differentiation Cell lines Cell proliferation Cyclin-dependent kinases Diet Enzymes Gene expression gene expression regulation Gene regulation Genes Genomics Health care Homeostasis humans Kinases MAP kinase Metabolism Mitochondria mitogen-activated protein kinase Molecular modelling muscle development muscle fibers Muscle function Muscle strength Muscles Musculoskeletal system myocytes Myogenesis Osteoporosis pain Protein biosynthesis Protein kinase Protein synthesis Protein turnover Proteins Receptors risk Sarcopenia Signal transduction Signaling Skeletal muscle Transcription transcription (genetics) Transcription factors Vitamin D Vitamin deficiency Mitochondria Muscle Protein synthesis Myogenesis Calcitriol
ISSN:	0954-4224, 1475-2700, 1475-2700
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Popis
Shrnutí:	Vitamin D receptor expression and associated function have been reported in various muscle models, including C 2 C 12 , L6 cell lines and primary human skeletal muscle cells. It is believed that 1,25-hydroxyvitamin D 3 (1,25(OH) 2 D 3 ), the active form of vitamin D, has a direct regulatory role in skeletal muscle function, where it participates in myogenesis, cell proliferation, differentiation, regulation of protein synthesis and mitochondrial metabolism through activation of various cellular signalling cascades, including the mitogen-activated protein kinase pathway(s). It has also been suggested that 1,25(OH) 2 D 3 and its associated receptor have genomic targets, resulting in regulation of gene expression, as well as non-genomic functions that can alter cellular behaviour through binding and modification of targets not directly associated with transcriptional regulation. The molecular mechanisms of vitamin D signalling, however, have not been fully clarified. Vitamin D inadequacy or deficiency is associated with muscle fibre atrophy, increased risk of chronic musculoskeletal pain, sarcopenia and associated falls, and may also decrease RMR. The main purpose of the present review is to describe the molecular role of vitamin D in skeletal muscle tissue function and metabolism, specifically in relation to proliferation, differentiation and protein synthesis processes. In addition, the present review also includes discussion of possible genomic and non-genomic pathways of vitamin D action.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	0954-4224 1475-2700 1475-2700
DOI:	10.1017/S0954422419000064