Peptide-based drug discovery: Current status and recent advances

[Display omitted] •A comprehensive compilation and analysis of FDA approved and under clinical trials peptide-based therapeutics.•Clinical trial peptides pipeline analysis reveals emerging areas and drug targets.•Recent advancements in the synthesis and diversification of peptides using unnatural am...

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Vydáno v:Drug discovery today Ročník 28; číslo 2; s. 103464
Hlavní autoři: Sharma, Komal, Sharma, Krishna K., Sharma, Anku, Jain, Rahul
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier Ltd 01.02.2023
Témata:
clinical trial
display technology
Drug Discovery - methods
FDA-approved drug
Gene Library
peptide drug discovery
peptide synthesis
peptide therapeutics
Peptides - therapeutic use
clinical trial
FDA-approved drug
display technology
peptide drug discovery
peptide synthesis
peptide therapeutics
ISSN:1359-6446, 1878-5832, 1878-5832
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Shrnutí:[Display omitted] •A comprehensive compilation and analysis of FDA approved and under clinical trials peptide-based therapeutics.•Clinical trial peptides pipeline analysis reveals emerging areas and drug targets.•Recent advancements in the synthesis and diversification of peptides using unnatural amino acids, late-stage and CH functionalization, and ligation techniques.•New advancements in peptide discovery through emphasis on emerging technologies such as DNA-encoded library and display techniques. The progressive development of peptides from reaction vessels to life-saving drugs via rigorous preclinical and clinical assessments is fascinating. Peptide therapeutics have gained momentum with the evolution of techniques in peptide chemistry, such as microwave irradiation in solid- and solution-phase synthesis, ligation chemistry, recombinant synthesis, and amalgamation with synthetic tools, including metal catalysis. Diverse emerging technologies, such as DNA-encoded libraries (DELs) and display techniques, are changing the status quo in the discovery of peptide therapeutics. In this review, we analyzed US Food and Drug Administration (FDA)-approved peptide drugs and those in clinical trials, highlighting recent advances in peptide-based drug discovery.
Bibliografie:ObjectType-Article-1
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ISSN:1359-6446
1878-5832
1878-5832
DOI:10.1016/j.drudis.2022.103464