G9a and DNMT1 inhibition modulates CDKN1A promoter methylation and the cell cycle leading to improvement in kidney fibrosis

Epigenetic mechanisms, including histone and DNA methylation, play a key role in kidney fibrosis, but the precise mechanism remains unclear. Concerted action between histone and DNA-methyltransferases like G9a and DNMT1 is a common theme in gene expression regulation. We investigated the role of G9a...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1867; no. 9; p. 130417
Main Authors:	Yang, Yuanyuan, Zhou, Zijian, Wang, Lujia, Gao, Peng, Wu, Zhong
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.09.2023
Subjects:	Cell cycle DNA methylation Epigenetic modification Histone methylation Kidney fibrosis DNMTs CDKN1A Histone methylation HMTs UHRF1 EHMT2 FN ChIP Cr α-SMA CCNB1 Epigenetic modification Cell cycle DNA methylation KEGG BUN Kidney fibrosis ON BCA GSEA MSP EMT ECM UUO TGFβ1 PDGF CDK1 Col-I PI
ISSN:	0304-4165, 1872-8006, 1872-8006
Online Access:	Get full text
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