Apoptosis during arenavirus infection: mechanisms and evasion strategies

In recent years there has been a greatly increased interest in the interactions of arenaviruses with the apoptotic machinery, and particularly the extent to which these interactions may be an important contributor to pathogenesis. Here we summarize the current state of our knowledge on this subject...

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Published in:Microbes and infection Vol. 20; no. 2; pp. 65 - 80
Main Authors: Meyer, Bjoern, Groseth, Allison
Format: Journal Article
Language:English
Published: France Elsevier Masson SAS 01.02.2018
Subjects:
Animals
Apoptosis
Arenaviridae Infections - immunology
Arenaviridae Infections - pathology
Arenaviridae Infections - virology
Arenavirus
Arenavirus - physiology
Caspases
Cell death
Humans
Immune Evasion
Immunity, Cellular
Immunopathology
Nucleoprotein
Nucleoproteins - metabolism
Signal Transduction
Virus Replication
Immunopathology
Nucleoprotein
Caspases
Cell death
Arenavirus
Apoptosis
ISSN:1286-4579, 1769-714X, 1769-714X
Online Access:Get full text
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Summary:In recent years there has been a greatly increased interest in the interactions of arenaviruses with the apoptotic machinery, and particularly the extent to which these interactions may be an important contributor to pathogenesis. Here we summarize the current state of our knowledge on this subject and address the potential for interplay with other immunological mechanisms known to be regulated by these viruses. We also compare and contrast what is known for arenavirus-induced apoptosis with observations from other segmented hemorrhagic fever viruses.
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ISSN:1286-4579
1769-714X
1769-714X
DOI:10.1016/j.micinf.2017.10.002