Suppression of 5-lipoxygenase gene is involved in triptolide-induced apoptosis in pancreatic tumor cell lines

Pancreatic adenocarcinoma is characterized by a poor prognosis and lack of response to conventional therapy. The purpose of this study was to investigate the effects of triptolide (TL) on proliferation and apoptosis of pancreatic cancer cells in vitro. We found that TL induced prominent growth inhib...

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Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1770; no. 7; pp. 1021 - 1027
Main Authors:	Zhou, G.X., Ding, X.L., Huang, J.F., Zhang, H., Wu, S.B.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.07.2007
Subjects:	5-lipoxygenase Apoptosis - drug effects Arachidonate 5-Lipoxygenase - metabolism Bcl-2 Blotting, Western Caspase 3 - metabolism Caspase-3 Cell Line, Tumor Cell Proliferation - drug effects Diterpenes - pharmacology DNA Primers Enzyme-Linked Immunosorbent Assay Epoxy Compounds - pharmacology Flow Cytometry Gene Expression Regulation - drug effects Humans In Situ Nick-End Labeling Leukotriene B4 - metabolism Luciferases Pancreas - cytology Pancreas - drug effects Pancreatic tumor Phenanthrenes - pharmacology Proto-Oncogene Proteins c-bcl-2 - metabolism Reverse Transcriptase Polymerase Chain Reaction Triptolide Pancreatic tumor Bcl-2 Triptolide TL LTB4 5-lipoxygenase 5-LOX Caspase-3
ISSN:	0304-4165, 0006-3002, 1872-8006
Online Access:	Get full text
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