Suppression of 5-lipoxygenase gene is involved in triptolide-induced apoptosis in pancreatic tumor cell lines

Pancreatic adenocarcinoma is characterized by a poor prognosis and lack of response to conventional therapy. The purpose of this study was to investigate the effects of triptolide (TL) on proliferation and apoptosis of pancreatic cancer cells in vitro. We found that TL induced prominent growth inhib...

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Veröffentlicht in:	Biochimica et biophysica acta Jg. 1770; H. 7; S. 1021 - 1027
Hauptverfasser:	Zhou, G.X., Ding, X.L., Huang, J.F., Zhang, H., Wu, S.B.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.07.2007
Schlagworte:	5-lipoxygenase Apoptosis - drug effects Arachidonate 5-Lipoxygenase - metabolism Bcl-2 Blotting, Western Caspase 3 - metabolism Caspase-3 Cell Line, Tumor Cell Proliferation - drug effects Diterpenes - pharmacology DNA Primers Enzyme-Linked Immunosorbent Assay Epoxy Compounds - pharmacology Flow Cytometry Gene Expression Regulation - drug effects Humans In Situ Nick-End Labeling Leukotriene B4 - metabolism Luciferases Pancreas - cytology Pancreas - drug effects Pancreatic tumor Phenanthrenes - pharmacology Proto-Oncogene Proteins c-bcl-2 - metabolism Reverse Transcriptase Polymerase Chain Reaction Triptolide Pancreatic tumor Bcl-2 Triptolide TL LTB4 5-lipoxygenase 5-LOX Caspase-3
ISSN:	0304-4165, 0006-3002, 1872-8006
Online-Zugang:	Volltext
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