A clinical case study of seven patients of autonomic dysfunction in post COVID-19 conditions with fever as the main clinical symptom: a case series

Many publications have reported that acute COVID-19 infection can cause autonomic dysfunction. In this series, we described seven patients who had recurrent fever after acute COVID-19 infection, and the possible pathophysiological basis is autonomic dysfunction. This was a retrospective study conduc...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Annals of medicine (Helsinki) Jg. 56; H. 1; S. 2402943
Hauptverfasser: Haihong, Liu, Nannan, Xu, Xiangzhu, Meng, Gang, Wang
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Taylor & Francis 31.12.2024
Schlagworte:
Adult
Aged
Autonomic Nervous System Diseases - diagnosis
Autonomic Nervous System Diseases - physiopathology
Case Report
COVID-19 - complications
COVID-19 - physiopathology
Female
Fever - etiology
Fever - physiopathology
Fever - virology
Fever of Unknown Origin - etiology
Fever of Unknown Origin - physiopathology
Fever of Unknown Origin - virology
Humans
Infectious Diseases
Male
Middle Aged
Post-Acute COVID-19 Syndrome
Retrospective Studies
SARS-CoV-2
post COVID-19 condition
autonomic dysfunction
Fever
ISSN:0785-3890, 1365-2060, 1365-2060
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Abstract Many publications have reported that acute COVID-19 infection can cause autonomic dysfunction. In this series, we described seven patients who had recurrent fever after acute COVID-19 infection, and the possible pathophysiological basis is autonomic dysfunction. This was a retrospective study conducted at the Qilu Hospital of Shandong University from January 2023 to March 2023. Patients who were hospitalized in the Department of Infectious Diseases with a diagnosis of fever of unknown origin. Between January and March 2023, a total of seven patients with autonomic dysfunction in post-COVID condition, who had recurrent fever accompanied by electrolyte imbalances and other manifestations of autonomic dysfunction. The median age of these patients was relatively high, and they were mostly indoor workers with comorbidities such as diabetes and chronic hypertension. Physical cooling and correction of electrolyte imbalances with medication were effective treatments. The COVID-19 infection can lead to autonomic dysfunction, which manifests not only as tachycardia and blood pressure abnormalities, but may also be the pathophysiological mechanism underlying recurrent fever in post-COVID cases.
AbstractList In this series, we describe seven patients who had recurrent fever after acute COVID-19 infection, and the possible pathophysiological basis is autonomic dysfunction.This case series highlights the concept of long COVID syndrome and provides a basis for clinicians to identify and treat these patients appropriately.
Many publications have reported that acute COVID-19 infection can cause autonomic dysfunction. In this series, we described seven patients who had recurrent fever after acute COVID-19 infection, and the possible pathophysiological basis is autonomic dysfunction.BACKGROUNDMany publications have reported that acute COVID-19 infection can cause autonomic dysfunction. In this series, we described seven patients who had recurrent fever after acute COVID-19 infection, and the possible pathophysiological basis is autonomic dysfunction.This was a retrospective study conducted at the Qilu Hospital of Shandong University from January 2023 to March 2023. Patients who were hospitalized in the Department of Infectious Diseases with a diagnosis of fever of unknown origin.PATIENTSThis was a retrospective study conducted at the Qilu Hospital of Shandong University from January 2023 to March 2023. Patients who were hospitalized in the Department of Infectious Diseases with a diagnosis of fever of unknown origin.Between January and March 2023, a total of seven patients with autonomic dysfunction in post-COVID condition, who had recurrent fever accompanied by electrolyte imbalances and other manifestations of autonomic dysfunction. The median age of these patients was relatively high, and they were mostly indoor workers with comorbidities such as diabetes and chronic hypertension. Physical cooling and correction of electrolyte imbalances with medication were effective treatments.RESULTSBetween January and March 2023, a total of seven patients with autonomic dysfunction in post-COVID condition, who had recurrent fever accompanied by electrolyte imbalances and other manifestations of autonomic dysfunction. The median age of these patients was relatively high, and they were mostly indoor workers with comorbidities such as diabetes and chronic hypertension. Physical cooling and correction of electrolyte imbalances with medication were effective treatments.The COVID-19 infection can lead to autonomic dysfunction, which manifests not only as tachycardia and blood pressure abnormalities, but may also be the pathophysiological mechanism underlying recurrent fever in post-COVID cases.CONCLUSIONSThe COVID-19 infection can lead to autonomic dysfunction, which manifests not only as tachycardia and blood pressure abnormalities, but may also be the pathophysiological mechanism underlying recurrent fever in post-COVID cases.
Many publications have reported that acute COVID-19 infection can cause autonomic dysfunction. In this series, we described seven patients who had recurrent fever after acute COVID-19 infection, and the possible pathophysiological basis is autonomic dysfunction. This was a retrospective study conducted at the Qilu Hospital of Shandong University from January 2023 to March 2023. Patients who were hospitalized in the Department of Infectious Diseases with a diagnosis of fever of unknown origin. Between January and March 2023, a total of seven patients with autonomic dysfunction in post-COVID condition, who had recurrent fever accompanied by electrolyte imbalances and other manifestations of autonomic dysfunction. The median age of these patients was relatively high, and they were mostly indoor workers with comorbidities such as diabetes and chronic hypertension. Physical cooling and correction of electrolyte imbalances with medication were effective treatments. The COVID-19 infection can lead to autonomic dysfunction, which manifests not only as tachycardia and blood pressure abnormalities, but may also be the pathophysiological mechanism underlying recurrent fever in post-COVID cases.
Author Gang, Wang
Xiangzhu, Meng
Nannan, Xu
Haihong, Liu
Author_xml – sequence: 1
  givenname: Liu
  surname: Haihong
  fullname: Haihong, Liu
  organization: Department of Infectious Disease, Qilu Hospital of Shandong University, Jinan, Shandong, China
– sequence: 2
  givenname: Xu
  surname: Nannan
  fullname: Nannan, Xu
  organization: Department of Infectious Disease, Qilu Hospital of Shandong University, Jinan, Shandong, China
– sequence: 3
  givenname: Meng
  surname: Xiangzhu
  fullname: Xiangzhu, Meng
  organization: Department of Gastroenterology, Shandong Rongjun General Hospital, Jinan, China
– sequence: 4
  givenname: Wang
  orcidid: 0000-0002-4584-3859
  surname: Gang
  fullname: Gang, Wang
  organization: Department of Infectious Disease, Qilu Hospital of Shandong University, Jinan, Shandong, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/39624957$$D View this record in MEDLINE/PubMed
BookMark eNpVkU1v1DAQhi1URLeFnwDykUuWcfyRmAuqFmgrVeoFuFqzjs0aJfYSO632d_CHSdTtCk4jzTx6X42eC3IWU3SEvGWwZtDCB2hayVsN6xpqsa4F1FrwF2TFuJJVDQrOyGphqgU6Jxc5_wKAumHwipxzrWqhZbMif66o7UMMFntqMTuay9QdaPI0uwcX6R5LcLHkZYNTSTENwdLukP0UbQkp0jBDKRe6uf9x-7limtoUu7CcMn0MZUf9HDRSzLTsHB1w5k-N-TDsSxo-UjyWuzG4_Jq89Nhn9-Y4L8n3r1--bW6qu_vr283VXWW5glLVtsW2c0ogaFSy8cqK1m9x2zhoOLbWtlJ4r4VE4NiBhwast15qx7XVwC_Jp6fc_bQdXGfnP0fszX4MA44HkzCY_y8x7MzP9GAYU0w1spkT3h8TxvR7crmYIWTr-h6jS1M2nAnQtQLVzui7f8tOLc8qZkA-AXZMOY_OnxAGZlFunpWbRbk5Kud_AcMMoRw
Cites_doi 10.1007/s10286-021-00803-8
10.1007/s10286-020-00733-x
10.1007/s11910-022-01240-4
10.19102/icrm.2020.111102
10.1016/s1047-9651(02)00121-3
10.1016/j.radcr.2021.05.081
10.1002/mus.25551
10.1007/s10286-020-00727-9
10.1007/s12026-021-09185-5
10.1056/NEJMra2111003
10.1097/00005792-196102000-00001
10.1038/s41590-021-01104-y
10.1007/s00415-021-10735-y
10.1038/s41591-021-01283-z
10.1530/EJE-13-1020
10.1007/s11239-021-02549-6
10.1007/s10286-021-00783-9
10.1016/S1473-3099(21)00703-9
10.1253/circj.CJ-88-0020
10.1016/j.ensci.2020.100276
10.1016/B978-0-12-804766-8.00008-X
10.1007/s11916-011-0181-7
ContentType Journal Article
Copyright 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group 2024 The Author(s)
Copyright_xml – notice: 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group 2024 The Author(s)
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
DOI 10.1080/07853890.2024.2402943
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
DocumentTitleAlternate L. Haihong et al
EISSN 1365-2060
ExternalDocumentID PMC11616757
39624957
10_1080_07853890_2024_2402943
Genre Journal Article
GroupedDBID ---
00X
03L
0YH
23M
36B
4.4
5GY
5RE
AAFWJ
AALUX
AAYXX
ABLKL
ABUPF
ACGEJ
ACGFS
ADCVX
ADRBQ
ADXPE
AENEX
AEOZL
AFKVX
AFPKN
AGYJP
AIJEM
AJWEG
ALMA_UNASSIGNED_HOLDINGS
AQTUD
BABNJ
BLEHA
BOHLJ
CCCUG
CITATION
CS3
DKSSO
EBD
EBS
EMB
EMOBN
F5P
GROUPED_DOAJ
H13
HZ~
KRBQP
KSSTO
KWAYT
KYCEM
LJTGL
M4Z
O9-
OK1
P2P
RPM
SV3
TDBHL
TFDNU
TFL
TFW
V1S
WH7
~1N
.55
.GJ
34G
39C
3O-
53G
5VS
AALIY
AAORF
AAPXX
ABWCV
ABZEW
ADFZZ
AFFNX
AFLEI
AJVHN
AWYRJ
BRMBE
CAG
CGR
COF
CUY
CVF
CYYVM
CZDIS
DRXRE
DWTOO
ECM
EIF
EJD
JENTW
M44
NPM
NUSFT
OVD
QQXMO
TEORI
X7M
ZGI
ZXP
7X8
5PM
ID FETCH-LOGICAL-c360t-2c8a8de64a09a657f6c48fbab7e073a8cc854ff945a03ad0f070cfcf59e39c903
ISICitedReferencesCount 0
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001315094400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 0785-3890
1365-2060
IngestDate Tue Nov 04 02:04:15 EST 2025
Sat Sep 27 17:46:54 EDT 2025
Thu Apr 03 07:06:58 EDT 2025
Sat Nov 29 03:01:11 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords post COVID-19 condition
autonomic dysfunction
Fever
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c360t-2c8a8de64a09a657f6c48fbab7e073a8cc854ff945a03ad0f070cfcf59e39c903
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-4584-3859
OpenAccessLink http://dx.doi.org/10.1080/07853890.2024.2402943
PMID 39624957
PQID 3140926068
PQPubID 23479
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_11616757
proquest_miscellaneous_3140926068
pubmed_primary_39624957
crossref_primary_10_1080_07853890_2024_2402943
PublicationCentury 2000
PublicationDate 2024-12-31
PublicationDateYYYYMMDD 2024-12-31
PublicationDate_xml – month: 12
  year: 2024
  text: 2024-12-31
  day: 31
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Annals of medicine (Helsinki)
PublicationTitleAlternate Ann Med
PublicationYear 2024
Publisher Taylor & Francis
Publisher_xml – name: Taylor & Francis
References e_1_3_7_21_1
e_1_3_7_10_1
e_1_3_7_20_1
e_1_3_7_11_1
e_1_3_7_23_1
e_1_3_7_12_1
e_1_3_7_22_1
e_1_3_7_13_1
e_1_3_7_14_1
e_1_3_7_15_1
e_1_3_7_16_1
e_1_3_7_17_1
e_1_3_7_18_1
e_1_3_7_19_1
e_1_3_7_3_1
e_1_3_7_2_1
e_1_3_7_5_1
e_1_3_7_4_1
e_1_3_7_7_1
e_1_3_7_6_1
e_1_3_7_9_1
e_1_3_7_8_1
References_xml – ident: e_1_3_7_7_1
  doi: 10.1007/s10286-021-00803-8
– ident: e_1_3_7_15_1
  doi: 10.1007/s10286-020-00733-x
– ident: e_1_3_7_23_1
  doi: 10.1007/s11910-022-01240-4
– ident: e_1_3_7_14_1
  doi: 10.19102/icrm.2020.111102
– ident: e_1_3_7_10_1
  doi: 10.1016/s1047-9651(02)00121-3
– ident: e_1_3_7_12_1
  doi: 10.1016/j.radcr.2021.05.081
– ident: e_1_3_7_19_1
  doi: 10.1002/mus.25551
– ident: e_1_3_7_13_1
  doi: 10.1007/s10286-020-00727-9
– ident: e_1_3_7_6_1
  doi: 10.1007/s12026-021-09185-5
– ident: e_1_3_7_11_1
  doi: 10.1056/NEJMra2111003
– ident: e_1_3_7_9_1
  doi: 10.1097/00005792-196102000-00001
– ident: e_1_3_7_3_1
  doi: 10.1038/s41590-021-01104-y
– ident: e_1_3_7_8_1
  doi: 10.1007/s00415-021-10735-y
– ident: e_1_3_7_4_1
  doi: 10.1038/s41591-021-01283-z
– ident: e_1_3_7_18_1
  doi: 10.1530/EJE-13-1020
– ident: e_1_3_7_5_1
  doi: 10.1007/s11239-021-02549-6
– ident: e_1_3_7_17_1
  doi: 10.1007/s10286-021-00783-9
– ident: e_1_3_7_2_1
  doi: 10.1016/S1473-3099(21)00703-9
– ident: e_1_3_7_22_1
  doi: 10.1253/circj.CJ-88-0020
– ident: e_1_3_7_16_1
  doi: 10.1016/j.ensci.2020.100276
– ident: e_1_3_7_20_1
  doi: 10.1016/B978-0-12-804766-8.00008-X
– ident: e_1_3_7_21_1
  doi: 10.1007/s11916-011-0181-7
SSID ssj0002710
Score 2.4360158
Snippet Many publications have reported that acute COVID-19 infection can cause autonomic dysfunction. In this series, we described seven patients who had recurrent...
In this series, we describe seven patients who had recurrent fever after acute COVID-19 infection, and the possible pathophysiological basis is autonomic...
SourceID pubmedcentral
proquest
pubmed
crossref
SourceType Open Access Repository
Aggregation Database
Index Database
StartPage 2402943
SubjectTerms Adult
Aged
Autonomic Nervous System Diseases - diagnosis
Autonomic Nervous System Diseases - physiopathology
Case Report
COVID-19 - complications
COVID-19 - physiopathology
Female
Fever - etiology
Fever - physiopathology
Fever - virology
Fever of Unknown Origin - etiology
Fever of Unknown Origin - physiopathology
Fever of Unknown Origin - virology
Humans
Infectious Diseases
Male
Middle Aged
Post-Acute COVID-19 Syndrome
Retrospective Studies
SARS-CoV-2
Title A clinical case study of seven patients of autonomic dysfunction in post COVID-19 conditions with fever as the main clinical symptom: a case series
URI https://www.ncbi.nlm.nih.gov/pubmed/39624957
https://www.proquest.com/docview/3140926068
https://pubmed.ncbi.nlm.nih.gov/PMC11616757
Volume 56
WOSCitedRecordID wos001315094400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 1365-2060
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0002710
  issn: 0785-3890
  databaseCode: DOA
  dateStart: 20210101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVAWR
  databaseName: Taylor & Francis Journals Complete
  customDbUrl:
  eissn: 1365-2060
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0002710
  issn: 0785-3890
  databaseCode: TFW
  dateStart: 19890101
  isFulltext: true
  titleUrlDefault: https://www.tandfonline.com
  providerName: Taylor & Francis
– providerCode: PRVAWR
  databaseName: Taylor & Francis Open Access
  customDbUrl:
  eissn: 1365-2060
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0002710
  issn: 0785-3890
  databaseCode: 0YH
  dateStart: 20210101
  isFulltext: true
  titleUrlDefault: https://www.tandfonline.com
  providerName: Taylor & Francis
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lj9MwELbKghAXxJvyWBkJcVmlSvO0uVXLropUuhy6SzlFrmPTSjQtTbra5W_wl_hhzMR22rJ7WA5cospJ46jfV894MvMNIW-FFrFUbOJprkIvylPpsTDUXpzowFexH-parulskA6HbDzmn1ut364W5vx7WhTs4oIv_yvUMAZgY-nsP8Dd3BQG4DOADkeAHY43Ar63qXaUYKKMgCz6hCWKNTkh1TqDQ6wrU5Z8kF-WaOFc5uNyUVYHhydnHz94XY6Z6bnJ7DJhWw03WmGDGnRa5wIz2Zv6ysv5slrMTQm1mR6VlMttH3ij2exe7KObC_avxD4OW6GJvphNbcbwYLZuwtaisD2Vx83YGEj-7ed0XYd3lTXGmFVko-FfhB2z8Y2gUVFsluQ6D883XQc66poxu44bgfIdvtpFGfbI3IhBXTEYNsMyBa-Fcb-DD9DZun5XoHt4kh2fDgbZ6Gg8erf84WHvMnzHbxu53CK3gzTmuLb6X_uNPxCkRhPDPbOrI0OF9-vm3fWQrmx7_s7e3XKHRg_IfbuPoT3Dv4ekpYpH5O4nC-hj8qtHHSko8oDWNKQLTWsaUkdDHGloSLdoSGdwEdCQOhrSDQ0p0pDWNKSipEBDijTczGhp-J4KO3lNwifk9PhodNj3bAMQT4aJX3mBZILlKomEz0USpzqREdMTMUkVWCbBpGRxpDWPYuGHIvc12C-ppY5h3eGS--FTslcsCvUcM_hEzIXqxkpOIp3Hgssc3JQQS8e78KU26bgfPVsanZes6-RzLUoZopRZlNrkjYMmgxUZX7OJQi3WZRaihlyQ-Alrk2cGquaWIU-w2XvaJmwHxOYCVHvfPVPMprXqexf2ZrC7T1_cYOKX5N7mr_SK7FWrtXpN7sjzalau9mt6wjEds_06BvUHqAzMRQ
linkProvider Taylor & Francis
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+clinical+case+study+of+seven+patients+of+autonomic+dysfunction+in+post+COVID-19+conditions+with+fever+as+the+main+clinical+symptom%3A+a+case+series&rft.jtitle=Annals+of+medicine+%28Helsinki%29&rft.au=Haihong%2C+Liu&rft.au=Nannan%2C+Xu&rft.au=Xiangzhu%2C+Meng&rft.au=Gang%2C+Wang&rft.date=2024-12-31&rft.issn=1365-2060&rft.eissn=1365-2060&rft.volume=56&rft.issue=1&rft.spage=2402943&rft_id=info:doi/10.1080%2F07853890.2024.2402943&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0785-3890&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0785-3890&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0785-3890&client=summon