A clinical case study of seven patients of autonomic dysfunction in post COVID-19 conditions with fever as the main clinical symptom: a case series

Many publications have reported that acute COVID-19 infection can cause autonomic dysfunction. In this series, we described seven patients who had recurrent fever after acute COVID-19 infection, and the possible pathophysiological basis is autonomic dysfunction. This was a retrospective study conduc...

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Bibliographic Details
Published in:Annals of medicine (Helsinki) Vol. 56; no. 1; p. 2402943
Main Authors: Haihong, Liu, Nannan, Xu, Xiangzhu, Meng, Gang, Wang
Format: Journal Article
Language:English
Published: England Taylor & Francis 31.12.2024
Subjects:
Adult
Aged
Autonomic Nervous System Diseases - diagnosis
Autonomic Nervous System Diseases - physiopathology
Case Report
COVID-19 - complications
COVID-19 - physiopathology
Female
Fever - etiology
Fever - physiopathology
Fever - virology
Fever of Unknown Origin - etiology
Fever of Unknown Origin - physiopathology
Fever of Unknown Origin - virology
Humans
Infectious Diseases
Male
Middle Aged
Post-Acute COVID-19 Syndrome
Retrospective Studies
SARS-CoV-2
post COVID-19 condition
autonomic dysfunction
Fever
ISSN:0785-3890, 1365-2060, 1365-2060
Online Access:Get full text
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Summary:Many publications have reported that acute COVID-19 infection can cause autonomic dysfunction. In this series, we described seven patients who had recurrent fever after acute COVID-19 infection, and the possible pathophysiological basis is autonomic dysfunction. This was a retrospective study conducted at the Qilu Hospital of Shandong University from January 2023 to March 2023. Patients who were hospitalized in the Department of Infectious Diseases with a diagnosis of fever of unknown origin. Between January and March 2023, a total of seven patients with autonomic dysfunction in post-COVID condition, who had recurrent fever accompanied by electrolyte imbalances and other manifestations of autonomic dysfunction. The median age of these patients was relatively high, and they were mostly indoor workers with comorbidities such as diabetes and chronic hypertension. Physical cooling and correction of electrolyte imbalances with medication were effective treatments. The COVID-19 infection can lead to autonomic dysfunction, which manifests not only as tachycardia and blood pressure abnormalities, but may also be the pathophysiological mechanism underlying recurrent fever in post-COVID cases.
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ISSN:0785-3890
1365-2060
1365-2060
DOI:10.1080/07853890.2024.2402943