Physiologically‐based pharmacokinetic model predictions of inter‐ethnic differences in imatinib pharmacokinetics and dosing regimens

Aims This study implements a physiologically‐based pharmacokinetic (PBPK) modelling approach to investigate inter‐ethnic differences in imatinib pharmacokinetics and dosing regimens. Methods A PBPK model of imatinib was built in the Simcyp Simulator (version 17) integrating in vitro drug metabolism...

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Vydané v:	British journal of clinical pharmacology Ročník 88; číslo 4; s. 1735 - 1750
Hlavní autori:	Adiwidjaja, Jeffry, Gross, Annette S., Boddy, Alan V., McLachlan, Andrew J.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 01.02.2022
Predmet:	ethnic differences imatinib physiologically‐based pharmacokinetic simulation imatinib physiologically-based pharmacokinetic simulation ethnic differences
ISSN:	0306-5251, 1365-2125, 1365-2125
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