Relationship Between Midlife Cardiovascular Health and Late‐Life Physical Performance: The ARIC Study

Objectives To examine the association between midlife cardiovascular health and physical performance 25 years later. Design Cohort study (Atherosclerosis Risk in Communities Study); multinomial logistic and logistic regression adjusted for demographic characteristics and clinical measures. Setting F...

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Published in:Journal of the American Geriatrics Society (JAGS) Vol. 65; no. 5; pp. 1012 - 1018
Main Authors: Windham, B. Gwen, Harrison, Kimystian L., Lirette, Seth T., Lutsey, Pamela L., Pompeii, Lisa A., Gabriel, Kelley P., Koton, Silvia, Steffen, Lyn M., Griswold, Michael E., Mosley, Thomas H.
Format: Journal Article
Language:English
Published: United States 01.05.2017
Subjects:
Age Factors
Black People - statistics & numerical data
cardiovascular
Cardiovascular Diseases - ethnology
Cardiovascular Diseases - prevention & control
Exercise
Female
Humans
Male
Middle Aged
midlife
physical performance
Prospective Studies
Risk Factors
White People - statistics & numerical data
cardiovascular
physical performance
midlife
ISSN:0002-8614, 1532-5415
Online Access:Get full text
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Summary:Objectives To examine the association between midlife cardiovascular health and physical performance 25 years later. Design Cohort study (Atherosclerosis Risk in Communities Study); multinomial logistic and logistic regression adjusted for demographic characteristics and clinical measures. Setting Four U.S. communities: Forsyth County, North Carolina; Washington County, Maryland; Minneapolis, Minnesota; and Jackson, Mississippi. Participants: Individuals aged 54.2 ± 5.8 at baseline (N = 15,744; 55% female, 27% black). Measurements Cardiovascular health was measured at baseline using the American Heart Association's Life's Simple 7 (LS7) score (0–14) and LS7 component categories (poor, intermediate, ideal) for each risk factor. The Short Physical Performance Battery (SPPB) was used to quantify physical function as ordinal (0–12) and categorical (low (0–6), fair (7–9), good (10–12) outcomes. Results Mean baseline LS7 score was 7.9 ± 2.4; 6,144 (39%) individuals returned 25 years later for the fifth ARIC examination, at which point the SPPB was administered. Of 5,916 individuals who completed the SPPB, 3,288 (50%) had good physical performance. Each 1‐unit increase in LS7 score was associated with a 17% higher SPPB score (rate ratio (RR) = 1.17, 95% confidence interval (CI) = 1.15–1.19) and a 29% greater chance of having a late‐life SPPB score of 10 or greater compared to SPPB score of less than 10 (RR = 1.29, 95% CI = 1.25–1.34). Ideal baseline glucose (RR = 2.53, 95% CI = 2.24–2.87), smoking (RR = 1.97, 95% CI = 1.81–2.15), blood pressure (RR = 1.70, 95% CI = 1.54–1.88), body mass index (RR = 1.51, 95% CI = 1.37–1.66), and physical activity (RR = 1.31, 95% CI = 1.20–1.43) had the strongest associations with late‐life SPPB score, adjusting for other LS7 components. Conclusion Better cardiovascular health during midlife may lead better physical functioning in older age.
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ISSN:0002-8614
1532-5415
DOI:10.1111/jgs.14732