Differences in the induction of CD8+ T cell responses by subpopulations of dendritic cells from afferent lymph are related to IL-1α secretion

The major subset of dendritic cells (DC) from bovine afferent lymph expresses the SIRPα MyD‐1 antigen, but not CD11a or the antigen recognized by mAb CC81, and potently stimulates CD4+ and CD8+ T lymphocyte proliferation. The minor subpopulation, that is CD11a+CC81+MyD‐1−, effectively stimulates CD4...

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Bibliographic Details
Published in:	Journal of leukocyte biology Vol. 69; no. 2; pp. 271 - 279
Main Authors:	Hope, Jayne C., Sopp, Paul, Collins, Robert A, Howard, Chris J.
Format:	Journal Article
Language:	English
Published:	United States Society for Leukocyte Biology 01.02.2001
Subjects:	Adjuvants, Immunologic - genetics Adjuvants, Immunologic - pharmacology afferent lymph veiled cells Animals Antibodies, Monoclonal - analysis Cattle CD11 Antigens - biosynthesis CD11 Antigens - immunology CD8+ lymphocytes CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Cell Separation Cell Survival - immunology Cell-Free System - immunology Cells, Cultured Clonal Anergy Cytotoxicity, Immunologic Dendritic Cells - immunology Dendritic Cells - metabolism Down-Regulation - immunology Humans Immunophenotyping Interleukin-1 - genetics Interleukin-1 - pharmacology Interleukin-1 - secretion Interleukin-12 - genetics Interleukin-12 - pharmacology Interleukin-2 - secretion Interleukin-5 - secretion Interleukin-6 - genetics Interleukin-6 - pharmacology Isoantigens - immunology Lymph - cytology Lymph - immunology Lymphocyte Activation Recombinant Proteins - immunology Recombinant Proteins - pharmacology
ISSN:	0741-5400, 1938-3673
Online Access:	Get full text
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