Differences in the induction of CD8+ T cell responses by subpopulations of dendritic cells from afferent lymph are related to IL-1α secretion

The major subset of dendritic cells (DC) from bovine afferent lymph expresses the SIRPα MyD‐1 antigen, but not CD11a or the antigen recognized by mAb CC81, and potently stimulates CD4+ and CD8+ T lymphocyte proliferation. The minor subpopulation, that is CD11a+CC81+MyD‐1−, effectively stimulates CD4...

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Vydáno v:	Journal of leukocyte biology Ročník 69; číslo 2; s. 271 - 279
Hlavní autoři:	Hope, Jayne C., Sopp, Paul, Collins, Robert A, Howard, Chris J.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Society for Leukocyte Biology 01.02.2001
Témata:	Adjuvants, Immunologic - genetics Adjuvants, Immunologic - pharmacology afferent lymph veiled cells Animals Antibodies, Monoclonal - analysis Cattle CD11 Antigens - biosynthesis CD11 Antigens - immunology CD8+ lymphocytes CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Cell Separation Cell Survival - immunology Cell-Free System - immunology Cells, Cultured Clonal Anergy Cytotoxicity, Immunologic Dendritic Cells - immunology Dendritic Cells - metabolism Down-Regulation - immunology Humans Immunophenotyping Interleukin-1 - genetics Interleukin-1 - pharmacology Interleukin-1 - secretion Interleukin-12 - genetics Interleukin-12 - pharmacology Interleukin-2 - secretion Interleukin-5 - secretion Interleukin-6 - genetics Interleukin-6 - pharmacology Isoantigens - immunology Lymph - cytology Lymph - immunology Lymphocyte Activation Recombinant Proteins - immunology Recombinant Proteins - pharmacology
ISSN:	0741-5400, 1938-3673
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Abstract	The major subset of dendritic cells (DC) from bovine afferent lymph expresses the SIRPα MyD‐1 antigen, but not CD11a or the antigen recognized by mAb CC81, and potently stimulates CD4+ and CD8+ T lymphocyte proliferation. The minor subpopulation, that is CD11a+CC81+MyD‐1−, effectively stimulates CD4+ but not CD8+ T lymphocyte proliferation. CD11a+CC81+MyD‐1− DC did not induce anergy or death or secrete an inhibitory factor. However, supernatant from cultures of CD8+ T cells with CD11a−CC81−MyD‐1+ DC significantly enhanced proliferation of CD8+ T cells in response to CD11a+CC81+MyD‐1− DC, an effect that was blocked by interleukin (IL)‐1α, but not IL‐1β, specific mAb. The proliferation of CD8+ T cells with CD11a+CC81+MyD‐1− DC was also enhanced by adding IL‐1α. IL‐1β slightly enhanced proliferation, whereas IL‐2, IL‐6, IL‐12, and IL‐15 had no effect. We conclude that the failure to stimulate CD8+ T cell proliferation results from the lack of IL‐1α synthesis by this population, which may have important consequences in vivo.
AbstractList	The major subset of dendritic cells (DC) from bovine afferent lymph expresses the SIRP alpha MyD-1 antigen, but not CD11a or the antigen recognized by mAb CC81, and potently stimulates CD4+ and CD8+ T lymphocyte proliferation. The minor subpopulation, that is CD11a+ CC81+ MyD-1-, effectively stimulates CD4+ but not CD8+ T lymphocyte proliferation. CD11a+ CC81+ MyD-1- DC did not induce anergy or death or secrete an inhibitory factor. However, supernatant from cultures of CD8+ T cells with CD11a- CC81- MyD-1+ DC significantly enhanced proliferation of CD8+ T cells in response to CD11a+ CC81+ MyD-1- DC, an effect that was blocked by interleukin (IL)-1alpha, but not IL-1beta, specific mAb. The proliferation of CD8+ T cells with CD11a+ CC81+ MyD-1- DC was also enhanced by adding IL-1alpha. IL-1beta slightly enhanced proliferation, whereas IL-2, IL-6, IL-12, and IL-15 had no effect. We conclude that the failure to stimulate CD8+ T cell proliferation results from the lack of IL-1alpha synthesis by this population, which may have important consequences in vivo. The major subset of dendritic cells (DC) from bovine afferent lymph expresses the SIRPα MyD-1 antigen, but not CD11a or the antigen recognized by mAb CC81, and potently stimulates CD4+ and CD8+ T lymphocyte proliferation. The minor subpopulation, that is CD11a+CC81+MyD-1−, effectively stimulates CD4+ but not CD8+ T lymphocyte proliferation. CD11a+CC81+MyD-1− DC did not induce anergy or death or secrete an inhibitory factor. However, supernatant from cultures of CD8+ T cells with CD11a−CC81−MyD-1+ DC significantly enhanced proliferation of CD8+ T cells in response to CD11a+CC81+MyD-1− DC, an effect that was blocked by interleukin (IL)-1α, but not IL-1β, specific mAb. The proliferation of CD8+ T cells with CD11a+CC81+MyD-1− DC was also enhanced by adding IL-1α. IL-1β slightly enhanced proliferation, whereas IL-2, IL-6, IL-12, and IL-15 had no effect. We conclude that the failure to stimulate CD8+ T cell proliferation results from the lack of IL-1α synthesis by this population, which may have important consequences in vivo. The major subset of dendritic cells (DC) from bovine afferent lymph expresses the SIRP alpha MyD-1 antigen, but not CD11a or the antigen recognized by mAb CC81, and potently stimulates CD4+ and CD8+ T lymphocyte proliferation. The minor subpopulation, that is CD11a+ CC81+ MyD-1-, effectively stimulates CD4+ but not CD8+ T lymphocyte proliferation. CD11a+ CC81+ MyD-1- DC did not induce anergy or death or secrete an inhibitory factor. However, supernatant from cultures of CD8+ T cells with CD11a- CC81- MyD-1+ DC significantly enhanced proliferation of CD8+ T cells in response to CD11a+ CC81+ MyD-1- DC, an effect that was blocked by interleukin (IL)-1alpha, but not IL-1beta, specific mAb. The proliferation of CD8+ T cells with CD11a+ CC81+ MyD-1- DC was also enhanced by adding IL-1alpha. IL-1beta slightly enhanced proliferation, whereas IL-2, IL-6, IL-12, and IL-15 had no effect. We conclude that the failure to stimulate CD8+ T cell proliferation results from the lack of IL-1alpha synthesis by this population, which may have important consequences in vivo.The major subset of dendritic cells (DC) from bovine afferent lymph expresses the SIRP alpha MyD-1 antigen, but not CD11a or the antigen recognized by mAb CC81, and potently stimulates CD4+ and CD8+ T lymphocyte proliferation. The minor subpopulation, that is CD11a+ CC81+ MyD-1-, effectively stimulates CD4+ but not CD8+ T lymphocyte proliferation. CD11a+ CC81+ MyD-1- DC did not induce anergy or death or secrete an inhibitory factor. However, supernatant from cultures of CD8+ T cells with CD11a- CC81- MyD-1+ DC significantly enhanced proliferation of CD8+ T cells in response to CD11a+ CC81+ MyD-1- DC, an effect that was blocked by interleukin (IL)-1alpha, but not IL-1beta, specific mAb. The proliferation of CD8+ T cells with CD11a+ CC81+ MyD-1- DC was also enhanced by adding IL-1alpha. IL-1beta slightly enhanced proliferation, whereas IL-2, IL-6, IL-12, and IL-15 had no effect. We conclude that the failure to stimulate CD8+ T cell proliferation results from the lack of IL-1alpha synthesis by this population, which may have important consequences in vivo.
Author	Robert A Collins Jayne C. Hope Chris J. Howard Paul Sopp
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Snippet	The major subset of dendritic cells (DC) from bovine afferent lymph expresses the SIRPα MyD‐1 antigen, but not CD11a or the antigen recognized by mAb CC81, and... The major subset of dendritic cells (DC) from bovine afferent lymph expresses the SIRPα MyD-1 antigen, but not CD11a or the antigen recognized by mAb CC81, and... The major subset of dendritic cells (DC) from bovine afferent lymph expresses the SIRP alpha MyD-1 antigen, but not CD11a or the antigen recognized by mAb...
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SubjectTerms	Adjuvants, Immunologic - genetics Adjuvants, Immunologic - pharmacology afferent lymph veiled cells Animals Antibodies, Monoclonal - analysis Cattle CD11 Antigens - biosynthesis CD11 Antigens - immunology CD8+ lymphocytes CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Cell Separation Cell Survival - immunology Cell-Free System - immunology Cells, Cultured Clonal Anergy Cytotoxicity, Immunologic Dendritic Cells - immunology Dendritic Cells - metabolism Down-Regulation - immunology Humans Immunophenotyping Interleukin-1 - genetics Interleukin-1 - pharmacology Interleukin-1 - secretion Interleukin-12 - genetics Interleukin-12 - pharmacology Interleukin-2 - secretion Interleukin-5 - secretion Interleukin-6 - genetics Interleukin-6 - pharmacology Isoantigens - immunology Lymph - cytology Lymph - immunology Lymphocyte Activation Recombinant Proteins - immunology Recombinant Proteins - pharmacology
Title	Differences in the induction of CD8+ T cell responses by subpopulations of dendritic cells from afferent lymph are related to IL-1α secretion
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