Clonal Hematopoiesis: Somatic Mutations in Blood Cells and Atherosclerosis

The most important prognostic factor for atherosclerotic cardiovascular disease is age, independent of all other recognized risk factors. Recently, exome sequence analyses showed that somatic mutations in blood cells, a process termed clonal hematopoiesis, are common and increase in prevalence with...

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Veröffentlicht in:Circulation. Genomic and precision medicine Jg. 11; H. 7; S. e001926
Hauptverfasser: Natarajan, Pradeep, Jaiswal, Siddhartha, Kathiresan, Sekar
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.07.2018
Schlagworte:
blood cell
coronary artery disease
hematopoiesis
genetics
clonal evolution
hematologic neoplasms
human
ISSN:2574-8300, 2574-8300
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Zusammenfassung:The most important prognostic factor for atherosclerotic cardiovascular disease is age, independent of all other recognized risk factors. Recently, exome sequence analyses showed that somatic mutations in blood cells, a process termed clonal hematopoiesis, are common and increase in prevalence with age, with at least 1 in 10 adults older than 70 years affected. Carriers of clonal hematopoiesis have been shown to be not only at heightened risk for hematologic malignancy but also at increased risk for atherosclerotic cardiovascular disease. Here, we review the prior literature of clonal selection and expansion of hematopoietic stem cells and the evidence supporting its causal association with atherosclerotic cardiovascular disease.
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ISSN:2574-8300
2574-8300
DOI:10.1161/CIRCGEN.118.001926