The Link between Hematopoiesis and Atherosclerosis

Clinical evidence supporting a link between inflammation and atherosclerosis includes the results of the Canakinumab Antiinflammatory Thrombosis Outcomes Study (CANTOS), which showed that targeting inflammation improved cardiovascular outcomes. A recent study involving animal models provides a molec...

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Vydáno v:The New England journal of medicine Ročník 380; číslo 19; s. 1869 - 1871
Hlavní autoři: de Winther, Menno P.J, Lutgens, Esther
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Massachusetts Medical Society 09.05.2019
Témata:
Animal models
Arteriosclerosis
Atherosclerosis
Bone marrow
Cardiovascular disease
Cholesterol
Endothelium
Hematopoiesis
Humans
Inflammation
Metabolism
Molecular modelling
Monoclonal antibodies
Proteins
Thrombosis
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ISSN:0028-4793, 1533-4406, 1533-4406
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Shrnutí:Clinical evidence supporting a link between inflammation and atherosclerosis includes the results of the Canakinumab Antiinflammatory Thrombosis Outcomes Study (CANTOS), which showed that targeting inflammation improved cardiovascular outcomes. A recent study involving animal models provides a molecular explanation.
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMcibr1901397