Pan-cancer Transcriptomic Predictors of Perineural Invasion Improve Occult Histopathologic Detection

Perineural invasion (PNI) is associated with aggressive tumor behavior, recurrence, and metastasis, and can influence the administration of adjuvant treatment. However, standard histopathologic examination has limited sensitivity in detecting PNI and does not provide insights into its mechanistic un...

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Vydáno v:	Clinical cancer research Ročník 27; číslo 10; s. 2807
Hlavní autoři:	Guo, Jimmy A, Hoffman, Hannah I, Shroff, Stuti G, Chen, Peter, Hwang, Peter G, Kim, Daniel Y, Kim, Daniel W, Cheng, Stephanie W, Zhao, Daniel, Mahal, Brandon A, Alshalalfa, Mohammed, Niemierko, Andrzej, Wo, Jennifer Y, Loeffler, Jay S, Fernandez-Del Castillo, Carlos, Jacks, Tyler, Aguirre, Andrew J, Hong, Theodore S, Mino-Kenudson, Mari, Hwang, William L
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 15.05.2021
Témata:	Biomarkers, Tumor Computational Biology - methods Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Machine Learning Neoplasm Invasiveness Neoplasms - diagnosis Neoplasms - genetics Neoplasms - mortality Nerve Tissue - pathology Prognosis Proportional Hazards Models ROC Curve Transcriptome
ISSN:	1557-3265, 1557-3265
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