The effect of a next generation factor VIII mimetic bispecific antibody (Mim8) on assays of factor VIII activity and thrombin generation

Mim8 is a next generation bispecific antibody developed for the prophylactic treatment of hemophilia A. The sensitivity of activated plasma thromboplastin time (APTT), assays measuring factor VIII activity (FVIII:C) and thrombin generation to plasma containing Mim8 was assessed. Congenital severe he...

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Veröffentlicht in:	Journal of thrombosis and haemostasis Jg. 21; H. 3; S. 480 - 487
Hauptverfasser:	Bowyer, Annette Elizabeth, Kitchen, Steve, Ezban, Mirella
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Inc 01.03.2023
Schlagworte:	Animals Antibodies, Bispecific - therapeutic use bispecific antibody Cattle chromogenic Factor VIII - metabolism FVIII hemophilia Hemophilia A - drug therapy Hemostatics - therapeutic use Humans Indicators and Reagents one-stage Partial Thromboplastin Time Thrombin - metabolism Thromboplastin - therapeutic use one-stage bispecific antibody hemophilia chromogenic FVIII
ISSN:	1538-7836, 1538-7836
Online-Zugang:	Volltext
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