Dermal Capillary Clearance: Physiology and Modeling

Substances applied to the skin surface may permeate deeper tissue layers and pass into the body’s systemic circulation by entering blood or lymphatic vessels in the dermis. The purpose of this review is an in-depth analysis of the dermal clearance/exchange process and its constituents: transport thr...

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Vydáno v:Skin pharmacology and physiology Ročník 18; číslo 2; s. 55 - 74
Hlavní autoři: Kretsos, K., Kasting, G.B.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Basel, Switzerland S. Karger AG 01.03.2005
Témata:
Administration, Cutaneous
Animals
Capillaries - drug effects
Capillaries - physiology
Cell Membrane Permeability - drug effects
Dermis - blood supply
Dermis - drug effects
Humans
Metabolic Clearance Rate
Models, Biological
Review
Dermis
Clearance
Permeability
Lymphatics
Capillaries
Modeling
ISSN:1660-5527, 1660-5535
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Shrnutí:Substances applied to the skin surface may permeate deeper tissue layers and pass into the body’s systemic circulation by entering blood or lymphatic vessels in the dermis. The purpose of this review is an in-depth analysis of the dermal clearance/exchange process and its constituents: transport through the interstitium, permeability of the microvascular barrier and removal via the circulation. We adapt an ‘engineering’ viewpoint with emphasis on quantifying the dermal microcirculatory physiology, providing the theoretical framework for the physics of key transport processes and reviewing the available computational clearance models in a comparative manner. Selected experimental data which may serve as valuable input to modeling attempts are also reported.
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ISSN:1660-5527
1660-5535
DOI:10.1159/000083706