GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells

Understanding clonal evolution and cancer development requires experimental approaches for characterizing the consequences of somatic mutations on gene regulation. However, no methods currently exist that efficiently link high-content chromatin accessibility with high-confidence genotyping in single...

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Vydané v:	Cell stem cell Ročník 30; číslo 5; s. 722
Hlavní autori:	Turkalj, Sven, Jakobsen, Niels Asger, Groom, Angus, Metzner, Marlen, Riva, Simone G, Gür, E Ravza, Usukhbayar, Batchimeg, Salazar, Mirian Angulo, Hentges, Lance D, Mickute, Gerda, Clark, Kevin, Sopp, Paul, Davies, James O J, Hughes, Jim R, Vyas, Paresh
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 04.05.2023
Predmet:	Chromatin Gene Expression Regulation Genomics Genotype Humans Leukemia, Myeloid, Acute Transposases - genetics Transposases - metabolism leukemia stem cells single-cell ATAC-seq acute myeloid leukemia chromatin accessibility epigenomics single-cell technologies cancer evolution somatic mutation clonal tracking tumor heterogeneity
ISSN:	1875-9777, 1875-9777
On-line prístup:	Zistit podrobnosti o prístupe
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