Corneal neovascularization

The optical clarity of the cornea is essential for maintaining good visual acuity. Corneal neovascularization, which is a major cause of vision loss worldwide, leads to corneal opacification and often contributes to a cycle of chronic inflammation. While numerous factors prevent angiogenesis within...

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Bibliographic Details
Published in:Experimental eye research Vol. 202; p. 108363
Main Authors: Nicholas, Matthew P., Mysore, Naveen
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.01.2021
Subjects:
Angiogenesis
Angiogenesis Inhibitors - therapeutic use
Animals
Cornea - diagnostic imaging
Corneal neovascularization
Corneal Neovascularization - diagnosis
Corneal Neovascularization - drug therapy
Diagnostic Imaging - methods
Humans
Vascular endothelial growth factor (VEGF)
Vascular Endothelial Growth Factor A - antagonists & inhibitors
Angiogenesis
Corneal neovascularization
Vascular endothelial growth factor (VEGF)
ISSN:0014-4835, 1096-0007, 1096-0007
Online Access:Get full text
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Summary:The optical clarity of the cornea is essential for maintaining good visual acuity. Corneal neovascularization, which is a major cause of vision loss worldwide, leads to corneal opacification and often contributes to a cycle of chronic inflammation. While numerous factors prevent angiogenesis within the cornea, infection, inflammation, hypoxia, trauma, corneal degeneration, and corneal transplantation can all disrupt these homeostatic safeguards to promote neovascularization. Here, we summarize its etiopathogenesis and discuss the molecular biology of angiogenesis within the cornea. We then review the clinical assessment and diagnostic evaluation of corneal neovascularization. Finally, we describe current and emerging therapies. •Summarizes the etiologies and pathogenesis of corneal neovascularization.•Describes the molecular biology of inflammatory corneal neovascularization.•Reviews clinical assessment and diagnostic imaging of corneal neovascularization.•Discusses current and emerging therapies for corneal neovascularization.
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ISSN:0014-4835
1096-0007
1096-0007
DOI:10.1016/j.exer.2020.108363