Loss of ZNF215 imprinting is associated with poor five-year survival in patients with cytogenetically abnormal-acute myeloid leukemia

Genomic imprinting is a form of epigenetic regulation and imprinted genes are silenced in a parental-specific manner. Imprinting is associated with various human diseases and cancers, but its roles in leukemogenesis remains elusive. In this study, the expression of a panel of 16 human imprinted gene...

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Published in:Blood cells, molecules, & diseases Vol. 90; p. 102577
Main Authors: Yang, Ming-Yu, Lin, Pai-Mei, Yang, Chao-Hui, Hu, Ming-Luen, Chen, I-Ya, Lin, Sheng-Fung, Hsu, Cheng-Ming
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.09.2021
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Chromosome Aberrations
Cytogenetically abnormal-acute myeloid leukemia
Disease-Free Survival
DNA-Binding Proteins - biosynthesis
DNA-Binding Proteins - genetics
Epigenesis, Genetic
Female
Five-year survival
Gene Expression Regulation, Leukemic
Genomic Imprinting
Humans
Imprinted genes
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - metabolism
Leukemia, Myeloid, Acute - mortality
Male
Middle Aged
Neoplasm Proteins - biosynthesis
Neoplasm Proteins - genetics
Survival Rate
ZNF215
FAB
Five-year survival
ROC
Cytogenetically abnormal-acute myeloid leukemia
BM
Imprinted genes
AUC
CA-AML
Genomic imprinting
Ct
LDH
PB
HNSCC
WBC
qPCR
ZNF215
WHO
ISSN:1079-9796, 1096-0961, 1096-0961
Online Access:Get full text
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Summary:Genomic imprinting is a form of epigenetic regulation and imprinted genes are silenced in a parental-specific manner. Imprinting is associated with various human diseases and cancers, but its roles in leukemogenesis remains elusive. In this study, the expression of a panel of 16 human imprinted genes was investigated using real-time quantitative polymerase chain reaction and 8 of them were further validated in 114 patients newly diagnosed with cytogenetically abnormal-acute myeloid leukemia (CA-AML) and 85 healthy subjects. Our results demonstrated upregulated expression of 8 imprinted genes (C15orf2, COPG2, H19, IGF2, PEG3-AS1, PRIM2, SLC22A3 and ZNF215) was observed in patients with CA-AML (p < 0.001). Patients' survival days were negatively correlated with the expression levels of H19 (p = 0.024), PGE3-AS1 (p = 0.038), and ZNF215 (p = 0.012). Multivariate logistic regression analysis further revealed the expression level ZNF215 can be used as a predictor for five-year survival for patients with CA-AML (p = 0.009) with a hazard ratio of 0.870 (95.0% confident interval: 0.784–0.965). Our results demonstrated that loss of imprinting of imprinted genes is critical for the leukemogenesis of AML under CA condition, and loss of ZNF215 imprinting is associated with poor five-year survival of patients with CA-AML.
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ISSN:1079-9796
1096-0961
1096-0961
DOI:10.1016/j.bcmd.2021.102577