Association of mast cells and bone marrow reticulin fibrosis in patients with bcr-abl negative chronic myeloproliferative neoplasms

We aimed to investigate the association of bone marrow mast cell numbers (MCN) and the degree of reticulin fibrosis in patients with chronic myeloproliferative neoplasms (MPN). This was a case-control study that recruited 47 patients who were diagnosed with bcr-abl negative MPN. Thirty patients with...

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Bibliographic Details
Published in:Blood cells, molecules, & diseases Vol. 82; p. 102420
Main Author: Keski, Hakan
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.05.2020
Subjects:
Aged
Bone marrow fibrosis
CD34
Chronic Disease
Female
Hematologic Neoplasms - genetics
Hematologic Neoplasms - metabolism
Hematologic Neoplasms - pathology
Humans
Janus Kinase 2
Male
Mast cell
Mast Cells - metabolism
Mast Cells - pathology
Middle Aged
Mutation
Myeloproliferative Disorders - genetics
Myeloproliferative Disorders - metabolism
Myeloproliferative Disorders - pathology
Myeloproliferative neoplasm
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Primary Myelofibrosis - genetics
Primary Myelofibrosis - metabolism
Primary Myelofibrosis - pathology
Reticulin - genetics
Reticulin - metabolism
Reticulin fiber
PBS
Bone marrow fibrosis
PV
PMF
MPN
ET
Reticulin fiber
MCN
BMF
Mast cell
CD34
Myeloproliferative neoplasm
WHO
ISSN:1079-9796, 1096-0961, 1096-0961
Online Access:Get full text
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Summary:We aimed to investigate the association of bone marrow mast cell numbers (MCN) and the degree of reticulin fibrosis in patients with chronic myeloproliferative neoplasms (MPN). This was a case-control study that recruited 47 patients who were diagnosed with bcr-abl negative MPN. Thirty patients with lymphoma served as controls. JAK2 mutation was studied and all subjects underwent bone marrow biopsy at the time of diagnosis. Mast and CD34+ cells were counted. Marrow reticulin fiber was graded. Thirty-four patients had essential thrombocythemia (ET), 8 patients had primary myelofibrosis (PMF) and 5 patients had polycythemia vera (PV). Fourteen MPN patients had JAK2, whereas the controls had not. MCN was higher in patients than controls (p = 0.001). There was no significant difference regarding CD34. Reticulin fibrosis was present in 57.4% of MPN patients, whereas there was any in controls. PMF patients had more CD34 + cells than PV and ET. PMF patients had more reticulin fibers compared with other subgroups (p < 0.001). MCN, but not CD34+ cell counts, was significantly higher in JAK2(+) patients than JAK2(−) patients. MCN and reticulin fibrosis were significantly increased in MPN patients. JAK2 positivity had significantly increased MCN compared to patients without JAK2. JAK2 was associated with increased reticulin fibrosis.
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ISSN:1079-9796
1096-0961
1096-0961
DOI:10.1016/j.bcmd.2020.102420