The global burden of metabolic disease: Data from 2000 to 2019

Global estimates of prevalence, deaths, and disability-adjusted life years (DALYs) from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 were examined for metabolic diseases (type 2 diabetes mellitus [T2DM], hypertension, and non-alcoholic fatty liver disease [NAFLD]). For metabo...

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Published in:Cell metabolism Vol. 35; no. 3; p. 414
Main Authors: Chew, Nicholas W S, Ng, Cheng Han, Tan, Darren Jun Hao, Kong, Gwyneth, Lin, Chaoxing, Chin, Yip Han, Lim, Wen Hui, Huang, Daniel Q, Quek, Jingxuan, Fu, Clarissa Elysia, Xiao, Jieling, Syn, Nicholas, Foo, Roger, Khoo, Chin Meng, Wang, Jiong-Wei, Dimitriadis, Georgios K, Young, Dan Yock, Siddiqui, Mohammad Shadab, Lam, Carolyn S P, Wang, Yibin, Figtree, Gemma A, Chan, Mark Y, Cummings, David E, Noureddin, Mazen, Wong, Vincent Wai-Sun, Ma, Ronald Ching Wan, Mantzoros, Christos S, Sanyal, Arun, Muthiah, Mark Dhinesh
Format: Journal Article
Language:English
Published: United States 07.03.2023
Subjects:
Diabetes Mellitus, Type 2 - epidemiology
Global Burden of Disease
Humans
Hypertension
Metabolic Diseases - epidemiology
Non-alcoholic Fatty Liver Disease
Obesity - epidemiology
Quality-Adjusted Life Years
Risk Factors
non-alcoholic fatty liver disease
disparity
disability-adjusted life years
global burden of disease
mortality
diabetes mellitus
metabolic disease
hypertension
global burden
obesity
ISSN:1932-7420, 1932-7420
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Summary:Global estimates of prevalence, deaths, and disability-adjusted life years (DALYs) from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 were examined for metabolic diseases (type 2 diabetes mellitus [T2DM], hypertension, and non-alcoholic fatty liver disease [NAFLD]). For metabolic risk factors (hyperlipidemia and obesity), estimates were limited to mortality and DALYs. From 2000 to 2019, prevalence rates increased for all metabolic diseases, with the greatest increase in high socio-demographic index (SDI) countries. Mortality rates decreased over time in hyperlipidemia, hypertension, and NAFLD, but not in T2DM and obesity. The highest mortality was found in the World Health Organization Eastern Mediterranean region, and low to low-middle SDI countries. The global prevalence of metabolic diseases has risen over the past two decades regardless of SDI. Urgent attention is needed to address the unchanging mortality rates attributed to metabolic disease and the entrenched sex-regional-socioeconomic disparities in mortality.
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ISSN:1932-7420
1932-7420
DOI:10.1016/j.cmet.2023.02.003