A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease β-site amyloid precursor protein cleaving enzyme 1 (BACE-1)

The clinically important anticoagulant heparin, a member of the glycosaminoglycan family of carbohydrates that is extracted predominantly from porcine and bovine tissue sources, has previously been shown to inhibit the β-site amyloid precursor protein cleaving enzyme 1 (BACE-1), a key drug target in...

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Veröffentlicht in:	Carbohydrate research Jg. 525; S. 108747
Hauptverfasser:	Mycroft-West, Courtney J., Devlin, Anthony J., Cooper, Lynsay C., Guimond, Scott E., Procter, Patricia, Miller, Gavin J., Guerrini, Marco, Fernig, David G., Yates, Edwin A., Lima, Marcelo A., Skidmore, Mark A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier Ltd 01.03.2023
Schlagworte:	Alzheimer disease Alzheimer Disease - drug therapy Alzheimer's disease amyloid Amyloid beta-Peptides Amyloid beta-Protein Precursor - metabolism Amyloid beta-Protein Precursor - therapeutic use Amyloid Precursor Protein Secretases Amyloid-β Animals anticoagulant activity anticoagulants Anticoagulants - chemistry BACE-1 Cattle chondroitin sulfate Chondroitin sulphate enzymes family glucosamine Glycosaminoglycan Glycosaminoglycans - pharmacology heparan sulfate Heparan sulphate Heparin Heparin - pharmacology inflammation Mammals - metabolism oxidative stress Pectinidae - metabolism peptides phosphorylation Placopecten magellanicus provenance Swine therapeutics β-secretase β-site amyloid precursor protein cleaving enzyme 1 β-site amyloid precursor protein cleaving enzyme 1 Placopecten magellanicus Heparan sulphate BACE-1 β-secretase Glycosaminoglycan Amyloid-β Chondroitin sulphate Heparin Alzheimer's disease
ISSN:	0008-6215, 1873-426X, 1873-426X
Online-Zugang:	Volltext
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