Performance of small-domain monolithic silica columns in nano-liquid chromatography and comparison with commercial packed bed columns with 2 µm particles

•Monolithic silica columns with sub-2 µm domain size have been synthesized.•The produced monolith columns provide a high column efficiency (H = ~4 µm).•Peak capacities (np) are 30‒40% higher than in a commercial particle column.•A high repeatability of the performance of the fabricated columns is de...

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Bibliographic Details

Published in:	Journal of Chromatography A Vol. 1616; p. 460804
Main Authors:	Hara, Takeshi, Izumi, Yoshihiro, Hata, Kosuke, V. Baron, Gino, Bamba, Takeshi, Desmet, Gert
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 12.04.2020
Subjects:	Column efficiency cytochrome c liquid chromatography Monolithic silica Packed bed column Peak capacity permeability silica Small domain size standard deviation Packed bed column Column efficiency Small domain size Monolithic silica Peak capacity
ISSN:	0021-9673, 1873-3778, 1873-3778
Online Access:	Get full text
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