Vascularized lymph node transfer for treatment of lymphedema: a comprehensive literature review

A comprehensive literature review of VLNT with updates and comparisons on current application, techniques, results, studies and possible future implications. Lymphedema is a debilitating condition that often results secondary to treatment of cancer. Unfortunately there is no cure. However, microsurg...

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Vydané v:Annals of surgery Ročník 261; číslo 5; s. 1013
Hlavní autori: Raju, Ashvin, Chang, David W
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.05.2015
Predmet:
Animals
Humans
Lymph Nodes - blood supply
Lymph Nodes - physiology
Lymph Nodes - transplantation
Lymphangiogenesis
Lymphedema - surgery
Surgical Flaps - blood supply
ISSN:1528-1140, 1528-1140
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Popis
Shrnutí:A comprehensive literature review of VLNT with updates and comparisons on current application, techniques, results, studies and possible future implications. Lymphedema is a debilitating condition that often results secondary to treatment of cancer. Unfortunately there is no cure. However, microsurgical procedures such as VLNT has gained popularity as there have been increasing reports that VLNT may help alleviate the severity of lymphedema. A review of literature was conducted over major medical indices (PubMed-MEDLINE, Factiva, Scopus, Sciencedirect, EMBASE). Search terms were focused on vascularized, lymph node transfer (also autologous, lymph node transplant) to cover both human and animal studies. Each study was verified for the nature of the procedure; a free microsurgical flap containing lymph nodes for the purpose of relieving lymphedema. There are human and animal studies that individually report clear benefits, but because of methodological shortcomings comparative studies with uniform patient selection and monitoring are lacking. Although the results with the use of VLNT for treatment of lymphedema have been largely positive, further exploration into standardized protocols for diagnosis, treatment optimization, and patient outcomes assessment is needed.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1528-1140
1528-1140
DOI:10.1097/SLA.0000000000000763