The Gastroenteropancreatic Neuroendocrine Cell System and Its Tumors: The WHO Classification

: Although well established in medical terminology, the term carcinoid is no longer adequate to cover the entire morphological and biological spectrum of neoplasms of the disseminated neuroendocrine cell system. Therefore, instead of carcinoid, the WHO classification published in 2000 uses the gener...

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Vydáno v:Annals of the New York Academy of Sciences Ročník 1014; číslo 1; s. 13 - 27
Hlavní autoři: KLÖPPEL, GÜNTER, PERREN, AUREL, HEITZ, PHILIPP U.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Oxford, UK Blackwell Publishing Ltd 01.04.2004
Témata:
carcinoids
classification
diagnosis
Gastrointestinal Neoplasms - classification
Gastrointestinal Neoplasms - pathology
Humans
neuroendocrine tumors
Neuroendocrine Tumors - classification
Neuroendocrine Tumors - pathology
Pancreatic Neoplasms - classification
Pancreatic Neoplasms - pathology
prognosis
World Health Organization
ISSN:0077-8923, 1749-6632
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Shrnutí:: Although well established in medical terminology, the term carcinoid is no longer adequate to cover the entire morphological and biological spectrum of neoplasms of the disseminated neuroendocrine cell system. Therefore, instead of carcinoid, the WHO classification published in 2000 uses the general terms neuroendocrine tumor and neuroendocrine carcinoma. In this review a classification of gastroenteropancreatic neuroendocrine tumors based on the WHO criteria is described. We also classify and comment on the most important tumor entities. On the basis of localization and of various morphological and biological criteria, we distinguish between benign neuroendocrine tumors, tumors with uncertain malignant potential, and tumors showing low‐grade and high‐grade malignancy.
Bibliografie:ark:/67375/WNG-R40KZTS6-0
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ArticleID:NYAS13
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1294.002