Rational design of DNA vaccines for the induction of human papillomavirus type 16 E6- and E7-specific cytotoxic T-cell responses

Many DNA vaccine candidates have been developed for the treatment of human papillomavirus type 16 (HPV16)-induced malignancies. Most of these vaccines consist of a fusion of E7 with a "carrier-protein" that functions to increase the potency of the vaccine. The nature of these carrier-prote...

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Vydáno v:	Human gene therapy Ročník 23; číslo 12; s. 1301
Hlavní autoři:	Oosterhuis, Koen, Aleyd, Esil, Vrijland, Kim, Schumacher, Ton N, Haanen, John B
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.12.2012
Témata:	Animals CD4-Positive T-Lymphocytes - immunology Cell Line Drug Design Endoplasmic Reticulum - metabolism Female Human papillomavirus 16 - immunology Humans Male Mice Mice, Inbred C57BL Oncogene Proteins, Viral - genetics Oncogene Proteins, Viral - immunology Papillomavirus E7 Proteins - genetics Papillomavirus E7 Proteins - immunology Papillomavirus Infections - prevention & control Papillomavirus Vaccines - genetics Papillomavirus Vaccines - immunology Recombinant Proteins - genetics Recombinant Proteins - immunology Repressor Proteins - genetics Repressor Proteins - immunology T-Lymphocytes, Cytotoxic - immunology Uterine Cervical Neoplasms - prevention & control Uterine Cervical Neoplasms - virology Vaccines, DNA - genetics Vaccines, DNA - immunology
ISSN:	1557-7422, 1557-7422
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